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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005947naa a2200901 4500
001oai:lup.lub.lu.se:259b90c6-94ad-4874-bad5-584c73ffa09e
003SwePub
008160401s2015 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/74105292 URI
0247 a https://doi.org/10.1016/j.ahj.2015.02.0202 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Mewton, Nathan4 aut
2451 0a Rationale and design of the Cyclosporine to ImpRove Clinical oUtcome in ST-elevation myocardial infarction patients (the CIRCUS trial)
264 1b Elsevier BV,c 2015
520 a Background Both acute myocardial ischemia and reperfusion contribute to cardiomyocyte death in ST-elevation myocardial infarction (STEMI). The final infarct size is the principal determinant of subsequent clinical outcome in STEMI patients. In a proof-of-concept phase II trial, the administration of cyclosporine prior to primary percutaneous coronary intervention (PPCI) has been associated with a reduction of infarct size in STEMI patients. Methods CIRCUS is an international, prospective, multicenter, randomized, double-blinded, placebo-controlled trial. The study is designed to compare the efficacy and safety of cyclosporine versus placebo, in addition to revascularization by PPCI, in patients presenting with acute anterior myocardial infarction within 12 hours of symptoms onset and initial TIMI flow <= 1 in the culprit left anterior descending coronary artery. Patients are randomized in a 1: 1 fashion to 2.5 mg/kg intravenous infusion of cyclosporine or matching placebo performed in theminutes preceding PCI. The primary efficacy end point of CIRCUS is a composite of 1-year all-cause mortality, rehospitalization for heart failure or heart failure worsening during initial hospitalization, and left ventricular adverse remodeling as determined by sequential transthoracic echochardiography. Secondary outcomes will be tested using a hierarchical sequence of left ventricular (LV) ejection fraction and absolute measurements of LV volumes. The composite of death and rehospitalization for heart failure or heart failure worsening during initial hospitalization will be further assessed at three years after the initial infarction. Results Recruitment lasted from April 2011 to February 2014. The CIRCUS trial has recruited 975 patients with acute anterior myocardial infarction. The 12-months results are expected to be available in 2015. Conclusions The CIRCUS trial is testing the hypothesis that cyclosporine in addition to early revascularization with PPCI compared to placebo in patients with acute anterior myocardial infarction reduces the incidence of death, heart failure and adverse LV remodeling at one-year follow-up.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Cung, Thien T.4 aut
7001 a Morel, Olivier4 aut
7001 a Cayla, Guillaume4 aut
7001 a Bonnefoy-Cudraz, Eric4 aut
7001 a Rioufol, Gilles4 aut
7001 a Angoulvant, Denis4 aut
7001 a Guerin, Patrice4 aut
7001 a Elbaz, Meyer4 aut
7001 a Delarche, Nicolas4 aut
7001 a Coste, Pierre4 aut
7001 a Vanzetto, Gerald4 aut
7001 a Metge, Marc4 aut
7001 a Aupetit, Jean-Francois4 aut
7001 a Jouve, Bernard4 aut
7001 a Motreff, Pascal4 aut
7001 a Tron, Christophe4 aut
7001 a Labeque, Jean-Noel4 aut
7001 a Steg, Pierre G.4 aut
7001 a Cottin, Yves4 aut
7001 a Range, Gregoire4 aut
7001 a Clerc, Jerome4 aut
7001 a Coussement, Patrick4 aut
7001 a Prunier, Fabrice4 aut
7001 a Moulin, Frederique4 aut
7001 a Roth, Olivier4 aut
7001 a Belle, Loic4 aut
7001 a Dubois, Phillipe4 aut
7001 a Barragan, Paul4 aut
7001 a Gilard, Martine4 aut
7001 a Piot, Christophe4 aut
7001 a Colin, Patrice4 aut
7001 a Morice, Marie-Claude4 aut
7001 a Monassier, Jean-Pierre4 aut
7001 a Ider, Omar4 aut
7001 a Dubois-Rande, Jean Luc P.4 aut
7001 a Unterseeh, Thierry4 aut
7001 a Lebreton, Herve4 aut
7001 a Beard, Thierry4 aut
7001 a Blanchard, Didier4 aut
7001 a Grollier, Gilles4 aut
7001 a Malquarti, Vincent4 aut
7001 a Staat, Patrick4 aut
7001 a Sudre, Arnaud4 aut
7001 a Hansson, Magnusu Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)expb-mha
7001 a Elmer, Eskilu Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)expb-eel
7001 a Boussaha, Inesse4 aut
7001 a Jossan, Claire4 aut
7001 a Torner, Anna4 aut
7001 a Claeys, Marc4 aut
7001 a Garcia-Dorado, David4 aut
7001 a Ovize, Michel4 aut
7102 a Klinisk fysiologi, Lundb Sektion V4 org
7730 t American Heart Journald : Elsevier BVg 169:6, s. 6-766q 169:6<6-766x 1097-6744x 0002-8703
8564 u http://dx.doi.org/10.1016/j.ahj.2015.02.020y FULLTEXT
8564 u https://hal-univ-rennes1.archives-ouvertes.fr/hal-01260554/file/Rationale%20and%20Design%20of%20the%20Cyclosporine.pdf
8564 8u https://lup.lub.lu.se/record/7410529
8564 8u https://doi.org/10.1016/j.ahj.2015.02.020

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