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Subcutaneous cladri...
Subcutaneous cladribine to treat multiple sclerosis : experience in 208 patients
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- Allen-Philbey, Kimberley (author)
- Royal London Hospital
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- De Trane, Stefania (author)
- Queen Mary University
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- Mao, Zhifeng (author)
- Guangzhou Medical University
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- Álvarez-González, Cesar (author)
- University Hospital Basel
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- Mathews, Joela (author)
- Royal London Hospital
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- MacDougall, Amy (author)
- London School of Hygiene and Tropical Medicine
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- Stennett, Andrea (author)
- Royal London Hospital
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- Zhou, Xia (author)
- Royal London Hospital
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- Yildiz, Ozlem (author)
- Royal London Hospital
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- Adams, Ashok (author)
- Royal London Hospital
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- Bianchi, Lucia (author)
- Queen Mary University
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- Blain, Camilla (author)
- St George's Hospital, London
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- Chapman, Christine (author)
- Queen Mary University
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- Chung, Karen (author)
- National Hospital for Neurology and Neurosurgery
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- Constantinescu, Cris S. (author)
- Nottingham University Hospitals NHS Trust
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- Dalton, Catherine (author)
- St George's Hospital, London
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- Farrell, Rachel A. (author)
- National Hospital for Neurology and Neurosurgery
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- Fisniku, Leonora (author)
- Brighton and Sussex University Hospitals NHS Trust
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- Ford, Helen (author)
- Leeds Teaching Hospitals NHS Trust
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- Gran, Bruno (author)
- Nottingham University Hospitals NHS Trust
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- Hobart, Jeremy (author)
- Plymouth University, Peninsula Schools of Medicine and Dentistry
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- Khaleeli, Zhaleh (author)
- National Hospital for Neurology and Neurosurgery
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- Mattoscio, Miriam (author)
- Imperial College London,Barking, Havering and Redbridge Hospital NHS Trust
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- Pavitt, Sue (author)
- University of Leeds
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- Pearson, Owen (author)
- Swansea Bay University Health Board
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Peruzzotti-Jametti, Luca (author)
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- Scalfari, Antonio (author)
- Charing Cross Hospital
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- Sharrack, Basil (author)
- Sheffield Teaching Hospitals
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- Silber, Eli (author)
- King's College Hospital
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- Tallantyre, Emma C. (author)
- University Hospital of Wales
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- Webb, Stewart (author)
- Queen Elizabeth University Hospital, Glasgow
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- Turner, Benjamin P. (author)
- Royal London Hospital
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- Marta, Monica (author)
- Royal London Hospital
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- Gnanapavan, Sharmilee (author)
- Royal London Hospital
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Giovannoni, Gavin (author)
- Royal London Hospital
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- Baker, David (author)
- Queen Mary University
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- Schmierer, Klaus (author)
- Queen Mary University,Royal London Hospital
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(creator_code:org_t)
- 2021-11-25
- 2021
- English.
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In: Therapeutic Advances in Neurological Disorders. - : SAGE Publications. - 1756-2856 .- 1756-2864. ; 14
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Abstract
Subject headings
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- Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak®) in multiple sclerosis (MS) patients. Methods: Litak® was offered to MS-patients irrespective of disease course. Litak® 10 mg was administered for 3–4 days during week 1. Based on lymphocyte count at week 4, patients received another 0–3 doses at week 5. A second course was administered 11 months later. Follow-up included adverse events, relapses, expanded disability status scale (EDSS), 9-hole-peg and Timed-25-foot-walking tests, no-evidence-of-disease-activity (NEDA), no-evidence-of-progression-or-active-disease (NEPAD), MRI, cerebrospinal fluid (CSF) neurofilament light chain (NfL), and lymphocyte counts. Results: In all, 208 patients received at least one course of treatment. Age at baseline was 44 (17–72) years and EDSS 0–8.5. Cladribine was generally well tolerated. One myocardial infarction, one breast cancer, and three severe skin reactions occurred without long-term sequelae. Two patients died (one pneumonia, one encephalitis). Lymphopenia grade 3 occurred in 5% and grade 4 in 0.5%. In 94 out of 116 pwMS with baseline and follow-up (BaFU) data after two treatment courses, EDSS remained stable or improved. At 18 months, 64% of patients with relapsing MS and BaFU data (n = 39) had NEDA. At 19 months, 62% of patients with progressive MS and BaFU data (n = 13) had NEPAD. Of n = 13 patients whose CSF-NfL at baseline was elevated, 77% were normalised within 12 months. Conclusions: Litak® was well tolerated. Effectiveness in relapsing MS appeared similar to cladribine tablets and was encouraging in progressive MS. Our data suggest cladribine may be safe and effective in MS-patients irrespective of their disease stage.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- cladribine
- disease-modifying treatment
- multiple sclerosis
- NEDA
- NEPAD
- treatment access
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Allen-Philbey, K ...
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De Trane, Stefan ...
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Mao, Zhifeng
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Álvarez-González ...
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Mathews, Joela
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MacDougall, Amy
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show more...
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Stennett, Andrea
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Zhou, Xia
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Yildiz, Ozlem
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Adams, Ashok
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Bianchi, Lucia
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Blain, Camilla
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Chapman, Christi ...
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Chung, Karen
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Constantinescu, ...
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Dalton, Catherin ...
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Farrell, Rachel ...
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Fisniku, Leonora
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Ford, Helen
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Gran, Bruno
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Hobart, Jeremy
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Khaleeli, Zhaleh
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Mattoscio, Miria ...
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Pavitt, Sue
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Pearson, Owen
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Peruzzotti-Jamet ...
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Scalfari, Antoni ...
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Sharrack, Basil
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Silber, Eli
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Tallantyre, Emma ...
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Webb, Stewart
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Turner, Benjamin ...
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Marta, Monica
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Gnanapavan, Shar ...
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Juliusson, Gunna ...
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Giovannoni, Gavi ...
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Baker, David
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Schmierer, Klaus
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Therapeutic Adva ...
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Lund University