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  • Yushkevich, Paul A.University of Pennsylvania (author)

Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-07-14
  • Oxford University Press (OUP),2021
  • 14 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:268b40ed-e218-4ede-9b5b-a62d9e8f2a20
  • https://lup.lub.lu.se/record/268b40ed-e218-4ede-9b5b-a62d9e8f2a20URI
  • https://doi.org/10.1093/brain/awab262DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of neurofibrillary tangle progression in the human brain, critical to the development of imaging biomarkers and interpretation of in vivo imaging studies in Alzheimer's disease, is based on conventional two-dimensional histology studies that only sample the brain sparsely. To address this limitation, ex vivo MRI and dense serial histological imaging in 18 human medial temporal lobe specimens (age 75.3 ± 11.4 years, range 45 to 93) were used to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe at individual and group levels. Group-level maps were obtained in the space of an in vivo brain template, and neurofibrillary tangles were measured in specific anatomical regions defined in this template. Three-dimensional maps of neurofibrillary tangle burden revealed significant variation along the anterior-posterior axis. While early neurofibrillary tangle pathology is thought to be confined to the transentorhinal region, we found similar levels of burden in this region and other medial temporal lobe subregions, including amygdala, temporopolar cortex, and subiculum/cornu ammonis 1 hippocampal subfields. Overall, the three-dimensional maps of neurofibrillary tangle burden presented here provide more complete information about the distribution of this neurodegenerative pathology in the region of the cortex where it first emerges in Alzheimer's disease, and may help inform the field about the patterns of pathology spread, as well as support development and validation of neuroimaging biomarkers.

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  • Muñoz López, MónicaUniversity of Castilla La Mancha (author)
  • Iñiguez De Onzoño Martin, María MercedesUniversity of Castilla La Mancha (author)
  • Ittyerah, RanjitUniversity of Pennsylvania (author)
  • Lim, SydneyUniversity of Pennsylvania (author)
  • Ravikumar, SadhanaUniversity of Pennsylvania (author)
  • Bedard, Madigan L.University of Pennsylvania (author)
  • Pickup, StephenUniversity of Pennsylvania (author)
  • Liu, WeixiaUniversity of Pennsylvania (author)
  • Wang, JiancongUniversity of Pennsylvania (author)
  • Hung, Ling YuUniversity of Pennsylvania (author)
  • Lasserve, JadeUniversity of Pennsylvania (author)
  • Vergnet, NicolasUniversity of Pennsylvania (author)
  • Xie, LongUniversity of Pennsylvania (author)
  • Dong, MengjinUniversity of Pennsylvania (author)
  • Cui, SalenaUniversity of Pennsylvania (author)
  • McCollum, LaurenUniversity of Pennsylvania (author)
  • Robinson, John L.University of Pennsylvania (author)
  • Schuck, TheresaUniversity of Pennsylvania (author)
  • De Flores, RobinInstitut Gustave Roussy (author)
  • Grossman, MurrayUniversity of Pennsylvania (author)
  • Tisdall, M. DylanUniversity of Pennsylvania (author)
  • Prabhakaran, KarthikUniversity of Pennsylvania (author)
  • Mizsei, GaborUniversity of Pennsylvania (author)
  • Das, Sandhitsu R.University of Pennsylvania (author)
  • Artacho-Pérula, EmilioUniversity of Castilla La Mancha (author)
  • Del Mar Arroyo Jiménez, Marl'aUniversity of Castilla La Mancha (author)
  • Marcos Raba, Marl'a PilarUniversity of Castilla La Mancha (author)
  • Molina Romero, Francisco JavierUniversity of Castilla La Mancha (author)
  • Cebada Sánchez, SandraUniversity of Castilla La Mancha (author)
  • Delgado González, José CarlosUniversity of Castilla La Mancha (author)
  • De La Rosa-Prieto, CarlosUniversity of Castilla La Mancha (author)
  • Córcoles Parada, MartaUniversity of Castilla La Mancha (author)
  • Lee, Edward B.University of Pennsylvania (author)
  • Trojanowski, John Q.University of Pennsylvania (author)
  • Ohm, Daniel T.University of Pennsylvania (author)
  • Wisse, Laura E.M.Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)la3343wi (author)
  • Wolk, David A.University of Pennsylvania (author)
  • Irwin, David J.University of Pennsylvania (author)
  • Insausti, RicardoUniversity of Castilla La Mancha (author)
  • University of PennsylvaniaUniversity of Castilla La Mancha (creator_code:org_t)

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  • In:Brain: Oxford University Press (OUP)144:9, s. 2784-27970006-89501460-2156

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