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Postprandial glycae...
Postprandial glycaemic dips predict appetite and energy intake in healthy individuals
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- Wyatt, Patrick (author)
- Zoe Global Limited
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- Berry, Sarah E. (author)
- King's College London
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- Finlayson, Graham (author)
- University of Leeds
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- O’Driscoll, Ruairi (author)
- University of Leeds
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- Hadjigeorgiou, George (author)
- Zoe Global Limited
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- Drew, David A. (author)
- Harvard University,Massachusetts General Hospital
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- Khatib, Haya Al (author)
- King's College London,Zoe Global Limited
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- Nguyen, Long H. (author)
- Massachusetts General Hospital,Harvard University
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- Linenberg, Inbar (author)
- Zoe Global Limited
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- Chan, Andrew T. (author)
- Harvard University,Massachusetts General Hospital
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- Spector, Tim D. (author)
- King's College London
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Wolf, Jonathan (author)
- Zoe Global Limited
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- Blundell, John (author)
- University of Leeds
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- Valdes, Ana M. (author)
- Nottingham Biomedical Research Centre (BRC),University of Nottingham,Nottingham City Hospital,King's College London
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(creator_code:org_t)
- 2021-04-12
- 2021
- English 7 s.
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In: Nature Metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 3:4, s. 523-529
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Abstract
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- Understanding how to modulate appetite in humans is key to developing successful weight loss interventions. Here, we showed that postprandial glucose dips 2–3 h after a meal are a better predictor of postprandial self-reported hunger and subsequent energy intake than peak glucose at 0–2 h and glucose incremental area under the blood glucose curve at 0–2 h. We explore the links among postprandial glucose, appetite and subsequent energy intake in 1,070 participants from a UK exploratory and US validation cohort, who consumed 8,624 standardized meals followed by 71,715 ad libitum meals, using continuous glucose monitors to record postprandial glycaemia. For participants eating each of the standardized meals, the average postprandial glucose dip at 2–3 h relative to baseline level predicted an increase in hunger at 2–3 h (r = 0.16, P < 0.001), shorter time until next meal (r = −0.14, P < 0.001), greater energy intake at 3–4 h (r = 0.19, P < 0.001) and greater energy intake at 24 h (r = 0.27, P < 0.001). Results were directionally consistent in the US validation cohort. These data provide a quantitative assessment of the relevance of postprandial glycaemia in appetite and energy intake modulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wyatt, Patrick
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Berry, Sarah E.
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Finlayson, Graha ...
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O’Driscoll, Ruai ...
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Hadjigeorgiou, G ...
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Drew, David A.
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show more...
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Khatib, Haya Al
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Nguyen, Long H.
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Linenberg, Inbar
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Chan, Andrew T.
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Spector, Tim D.
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Franks, Paul W.
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Wolf, Jonathan
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Blundell, John
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Valdes, Ana M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Nature Metabolis ...
- By the university
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Lund University