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Epithelial–mesenchy...
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Jolly, Mohit KumarRice University
(author)
Epithelial–mesenchymal transition, a spectrum of states : Role in lung development, homeostasis, and disease
- Article/chapterEnglish2018
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LIBRIS-ID:oai:lup.lub.lu.se:27544c38-ff51-4b63-b42b-91f8a3047a3a
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https://lup.lub.lu.se/record/27544c38-ff51-4b63-b42b-91f8a3047a3aURI
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https://doi.org/10.1002/dvdy.24541DOI
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Language:English
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Summary in:English
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
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Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.
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Ward, ChrisUniversity of Newcastle upon Tyne
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Eapen, Mathew SujiUniversity of Tasmania
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Myers, StephenUniversity of Tasmania
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Hallgren, OskarLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Department of Experimental Medical Science,Faculty of Medicine,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund(Swepub:lu)mmb-oha
(author)
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Levine, HerbertRice University
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Sohal, Sukhwinder SinghUniversity of Tasmania
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Rice UniversityUniversity of Newcastle upon Tyne
(creator_code:org_t)
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In:Developmental Dynamics: Wiley247:3, s. 346-3581058-8388
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