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BMPR1a Is Required ...
BMPR1a Is Required for the Optimal TGFβ1-Dependent CD207+ Langerhans Cell Differentiation and Limits Skin Inflammation through CD11c+ Cells
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- Hochgerner, Mathias (author)
- Medical University of Vienna,Medical University of Graz
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- Bauer, Thomas (author)
- Medical University of Vienna
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- Zyulina, Victoria (author)
- Medical University of Graz
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- Glitzner, Elisabeth (author)
- Medical University of Vienna
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- Warsi, Sarah (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematopoes och genterapi,Forskargrupper vid Lunds universitet,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Hematopoiesis and Gene Therapy,Lund University Research Groups,Skåne University Hospital
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- Konkel, Joanne E. (author)
- National Institute of Dental and Craniofacial Research
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- Tam-Amersdorfer, Carmen (author)
- Medical University of Graz
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- Chen, Wanjun (author)
- National Institute of Dental and Craniofacial Research
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- Karlsson, Stefan (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematopoes och genterapi,Forskargrupper vid Lunds universitet,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Hematopoiesis and Gene Therapy,Lund University Research Groups,Skåne University Hospital
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- Sibilia, Maria (author)
- Medical University of Vienna
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- Strobl, Herbert (author)
- Medical University of Graz
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Journal of Investigative Dermatology. - : Elsevier BV. - 0022-202X. ; 142:9, s. 3-2454
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Abstract
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- The cytokine TGFβ1 induces epidermal Langerhans cell (LC) differentiation from human precursors, an effect mediated through BMPR1a/ALK3 signaling, as revealed from ectopic expression and receptor inhibition studies. Whether TGFβ1‒BMPR1a signaling is required for LC differentiation in vivo remained incompletely understood. We found that TGFβ1-deficient mice show defective perinatal expansion and differentiation of LCs. LCs can be identified within the normal healthy human epidermis by anti-BMPR1a immunohistology staining. Deletion of BMPR1a in all (vav+) hematopoietic cells revealed that BMPR1a is required for the efficient TGFβ1-dependent generation of CD207+ LC-like cells from CD11c+ intermediates in vitro. Similarly, BMPR1a was required for the optimal induction of CD207 by preformed major histocompatibility complex II‒positive epidermal resident LC precursors in the steady state. BMPR1a expression is strongly upregulated in epidermal cells in psoriatic lesions, and BMPR1aΔCD11c mice showed a defect in the resolution phase of allergic and psoriatic skin inflammation. Moreover, whereas LCs from these mice expressed CD207, BMPR1a counteracted LC activation and migration from skin explant cultures. Therefore, TGFβ1‒BMPR1a signaling seems to be required for the efficient induction of CD207 during LC differentiation in the steady state, and bone marrow‒derived lesional CD11c+ cells may limit established skin inflammation through enhanced BMPR1a signaling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (subject category)
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- By the author/editor
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Hochgerner, Math ...
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Bauer, Thomas
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Zyulina, Victori ...
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Glitzner, Elisab ...
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Warsi, Sarah
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Konkel, Joanne E ...
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show more...
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Tam-Amersdorfer, ...
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Chen, Wanjun
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Karlsson, Stefan
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Sibilia, Maria
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Strobl, Herbert
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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Lund University