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Metabolic risk fact...
Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can)
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Ulmer, Hanno (author)
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Bjorge, Tone (author)
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Concin, Hans (author)
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Lukanova, Annekatrin (author)
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Borena, Wegene (author)
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- Häggström, Christel (author)
- Umeå universitet,Urologi och andrologi
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Engeland, Anders (author)
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- Almquist, Martin (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Jonsson, Håkan (author)
- Umeå universitet,Onkologi
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Selmer, Randi (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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Tretli, Steinar (author)
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Kleiner, Andrea (author)
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- Stocks, Tanja (author)
- Umeå universitet,Umeå University,Urologi och andrologi
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Nagel, Gabriele (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Gynecologic Oncology. - : Elsevier BV. - 1095-6859 .- 0090-8258. ; 125:2, s. 330-335
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http://umu.diva-port...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background. Little is known about the association between metabolic risk factors and cervical cancer carcinogenesis. Material and methods. During mean follow-up of 11 years of the Me-Can cohort (N = 288,834) 425 invasive cervical cancer cases were diagnosed. Hazard ratios (HRs) were estimated by the use of Cox proportional hazards regression models for quintiles and standardized z-scores (with a mean of 0 and a SD of 1) of BMI, blood pressure, glucose, cholesterol, triglycerides and MetS score. Risk estimates were corrected for random error in the measurements. Results. BMI (per 1SD increment) was associated with 12%, increase of cervical cancer risk, blood pressure with 25% and triglycerides with 39%, respectively. In models including all metabolic factors, the associations for blood pressure and triglycerides persisted. The metabolic syndrome (MetS) score was associated with 26% increased corrected risk of cervical cancer. Triglycerides were stronger associated with squamous cell carcinoma (HR 1.48; 95% CI, 1.20-1.83) than with adenocarcinoma (0.92, 0.54-1.56). Among older women cholesterol (50-70 years 1.34; 1.00-1.81), triglycerides (50-70 years 1.49, 1.03-2.16 and >= 70 years 1.54, 1.09-2.19) and glucose (>= 70 years 1.87, 1.13-3.11) were associated with increased cervical cancer risk. Conclusion. The presence of obesity, elevated blood pressure and triglycerides were associated with increased risk of cervical cancer. (C) 2012 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Metabolic factors
- Cervical cancer
- Epidemiology
- CONOR
- Metabolic factors
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ulmer, Hanno
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Bjorge, Tone
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Concin, Hans
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Lukanova, Anneka ...
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Manjer, Jonas
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Hallmans, Göran
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show more...
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Borena, Wegene
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Häggström, Chris ...
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Engeland, Anders
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Almquist, Martin
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Jonsson, Håkan
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Selmer, Randi
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Stattin, Pär
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Tretli, Steinar
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Kleiner, Andrea
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Stocks, Tanja
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Nagel, Gabriele
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Gynecologic Onco ...
- By the university
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Lund University
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Umeå University