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- Ji, JianguangLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Region Skåne (author)
Use of terbinafine and risk of death in patients with prostate cancer : A population-based cohort study
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2018-11-04
- Wiley,2019
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:27dbf388-213f-47ad-a13e-ccce5923379d
- https://lup.lub.lu.se/record/27dbf388-213f-47ad-a13e-ccce5923379dURI
- https://doi.org/10.1002/ijc.31901DOI
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- Language:English
- Summary in:English
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- Terbinafine is used for the treatment of several superficial fungal infections. In silico analyses and animal models suggest that terbinafine might have an anti-tumor effect. We aimed to explore whether subsequent administration of terbinafine might be associated with a lower mortality rate in patients with prostate cancer. We identified patients diagnosed with prostate cancer between July 2005 and December 2014 from the Swedish Cancer Registry, and linked them to the Swedish Prescribed Drug Register to ascertain subsequent use of terbinafine. A total of 799 patients received oral treatment of terbinafine during the study period with a mortality rate of 18.6 per 1,000 person-years. Compared to patients who did not use terbinafine and adjusting for a range of confounding factors, patients that received oral treatment of terbinafine had a decreased risk of death from prostate cancer (HR, 0.53; 95% CI, 0.38–0.73) and a decreased risk of death overall (HR, 0.64; 95% CI, 0.52–0.77). To account for indication bias, we further identified 907 patients who received topical use of terbinafine. However, the risk of death from prostate cancer in patients with topical use of terbinafine was 0.92 (95% CI 0.74–1.12) and the risk of death overall was 1.03 (95% CI 0.91–1.17) as compared to the controls, which suggests that there was no association between risk of death in patients with prostate cancer with topical use of terbinafine. These findings suggest that this drug's potential anti-tumor effect needs to be explored further.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- cohort study
- cox-regression
- epidemiology
- mortality
- prostate cancer
- register-based study
- terbinafine
Added entries (persons, corporate bodies, meetings, titles ...)
- Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Region Skåne(Swepub:lu)med-jsu (author)
- Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Region Skåne(Swepub:lu)med-ksq (author)
- Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:International Journal of Cancer: Wiley144:8, s. 1888-18950020-71361097-0215
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