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Intensive Imaging-b...
Intensive Imaging-based Follow-up of Surgically Treated Localised Renal Cell Carcinoma Does Not Improve Post-recurrence Survival : Results from a European Multicentre Database (RECUR)
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- Dabestani, Saeed (author)
- Lund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups,Skåne University Hospital
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- Beisland, Christian (author)
- University of Bergen,Haukeland University Hospital
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- Stewart, Grant D. (author)
- University of Cambridge
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- Bensalah, Karim (author)
- University of Rennes I
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- Gudmundsson, Eirikur (author)
- National University Hospital of Iceland
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- Lam, Thomas B. (author)
- University of Aberdeen,Aberdeen Royal Infirmary
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- Gietzmann, William (author)
- University of Aberdeen
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- Zakikhani, Paimaun (author)
- Aberdeen Royal Infirmary
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- Marconi, Lorenzo (author)
- University Hospital of Coimbra
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- Fernandéz-Pello, Sergio (author)
- University Hospital Cabueñes
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- Monagas, Serenella (author)
- San Agustin University Hospital
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Williams, Samuel Paul (author)
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- Torbrand, Christian (author)
- Lund University,Lunds universitet,Forskargruppen för oftalmologisk avbildning,Forskargrupper vid Lunds universitet,Ophthalmology Imaging Research Group,Lund University Research Groups,Skåne University Hospital
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- Powles, Thomas (author)
- Queen Mary University
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- Van Werkhoven, Erik (author)
- Netherlands Cancer Institute
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- Meijer, Richard (author)
- University Medical Center Utrecht
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- Volpe, Alessandro (author)
- University of Eastern Piedmont
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- Staehler, Michael (author)
- University Hospital Munich,Ludwig-Maximilian University of Munich
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- Ljungberg, Börje, 1949- (author)
- Umeå universitet,Umeå University,Urologi och andrologi
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- Bex, Axel (author)
- Netherlands Cancer Institute
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 75:2, s. 261-264
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Abstract
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- The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association with outcome after detection of disease recurrence. Consecutive patients with nonmetastatic RCC (n = 1612) treated with curative intent at 12 institutes across eight European countries between 2006 and 2011 were included. Recurrence occurred in 336 patients. Cross-sectional (computed tomography, magnetic resonance imaging) and conventional (chest X-ray, ultrasound) methods were used in 47% and 53%, respectively. More intensive FU imaging (more than twofold) than recommended by the European Association of Urology (EAU) was not associated with improved overall survival (OS) after recurrence. Overall, per patient treated for recurrence remaining alive with no evidence of disease, the number of FU images needed was 542, and 697 for high-risk patients. The study results suggest that use of more imaging during FU than that recommended in the 2017 EAU guidelines is unlikely to improve OS after recurrence. Prospective studies are needed to design optimal FU strategies for the future. Patient summary: After curative treatment for localised kidney cancer, follow-up is necessary to detect any recurrence. This study illustrates that increasing the imaging frequency during follow-up, even to double the number of follow-up imaging procedures recommended by the European Association of Urology guidelines, does not translate into improved survival for those with recurrence. After curative treatment for localised kidney cancer, a more intensive follow-up regimen than that recommended in the 2017 European Association of Urology guidelines did not improve overall survival among those experiencing recurrence, irrespective of the risk of recurrence. This suggests that an increase in follow-up imaging frequency is not cost-efficient. Prospective studies to identify more optimal follow-up strategies are needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Follow-up
- Imaging
- Kidney cancer
- Overall survival
- Radical surgery
- Kidney cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Dabestani, Saeed
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Beisland, Christ ...
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Stewart, Grant D ...
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Bensalah, Karim
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Gudmundsson, Eir ...
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Lam, Thomas B.
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show more...
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Gietzmann, Willi ...
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Zakikhani, Paima ...
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Marconi, Lorenzo
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Fernandéz-Pello, ...
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Monagas, Serenel ...
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Williams, Samuel ...
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Torbrand, Christ ...
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Powles, Thomas
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Van Werkhoven, E ...
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Meijer, Richard
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Volpe, Alessandr ...
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Staehler, Michae ...
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Ljungberg, Börje ...
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Bex, Axel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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European Urology
- By the university
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Lund University
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Umeå University