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Long-term weight ch...
Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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- Ellingjord-Dale, Merete (author)
- Imperial College London
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- Christakoudi, Sofia (author)
- Imperial College London,King's College London
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Dossus, Laure (author)
- International Agency for Research on Cancer, World Health Organization
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- Olsen, Anja (author)
- Danish Cancer Society,Aarhus University
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- Tjønneland, Anne (author)
- University of Copenhagen,Danish Cancer Society
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Schulze, Matthias B (author)
- German Institute of Human Nutrition,University of Potsdam
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- Masala, Giovanna (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Gram, Inger T (author)
- UiT The Arctic University of Norway, Tromsø
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- Skeie, Guri (author)
- UiT The Arctic University of Norway, Tromsø
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- Rosendahl, Ann H (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Sund, Malin (author)
- Umeå universitet,Umeå University,Kirurgi
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- Key, Tim (author)
- University of Oxford
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc (author)
- International Agency for Research on Cancer, World Health Organization
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- Heath, Alicia K (author)
- Imperial College London
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- Tsilidis, Konstantinos K (author)
- University of Ioannina,Imperial College London
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- Riboli, Elio (author)
- Imperial College London
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(creator_code:org_t)
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et al
- 2021-03-23
- 2022
- English 13 s.
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In: International Journal of Epidemiology. - : Oxford University Press (OUP). - 1464-3685 .- 0300-5771. ; 50:6, s. 1914-1926
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Abstract
Subject headings
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- BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.METHODS: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.RESULTS: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and-progesterone-receptor-positive (ER+PR+) breast cancer (HR = 1.46; 1.15-1.85).CONCLUSION: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Adult
- Body Mass Index
- Breast Neoplasms/epidemiology
- Female
- Humans
- Middle Aged
- Prospective Studies
- Risk Factors
- Weight Gain
- Young Adult
- long-term weight change
- breast cancer
- cohort study
- breast cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Ellingjord-Dale, ...
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Christakoudi, So ...
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Weiderpass, Elis ...
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Panico, Salvator ...
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Dossus, Laure
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Olsen, Anja
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show more...
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Tjønneland, Anne
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Kaaks, Rudolf
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Schulze, Matthia ...
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Masala, Giovanna
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Gram, Inger T
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Skeie, Guri
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Rosendahl, Ann H
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Sund, Malin
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Key, Tim
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Ferrari, Pietro
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Gunter, Marc
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Heath, Alicia K
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Tsilidis, Konsta ...
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Riboli, Elio
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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International Jo ...
- By the university
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Lund University
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Umeå University