Search: onr:"swepub:oai:lup.lub.lu.se:295670d1-e441-4401-b10c-eb73d462499b" >
The outer membrane ...
-
Bernhard, SaraLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
(author)
The outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
-
2014-04-25
-
Oxford University Press (OUP),2014
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:295670d1-e441-4401-b10c-eb73d462499b
-
https://lup.lub.lu.se/record/4429388URI
-
https://doi.org/10.1093/infdis/jiu241DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Factor H is an important complement regulator of the alternative pathway commonly recruited by pathogens for increased survival in the human host. The respiratory pathogen Moraxella catarrhalis that resides in the mucosa is highly serum resistant and causes otitis media in children and respiratory tract infections in individuals with underlying diseases. In this study, we show that M. catarrhalis binds factor H via the outer membrane protein OlpA. M. catarrhalis serum resistance was dramatically decreased in the absence of either OlpA or factor H, demonstrating that this inhibition of the alternative pathway significantly contributes to the virulence of M. catarrhalis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Fleury, ChristopheLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-cof
(author)
-
Su, Shanice YCLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-s_s
(author)
-
Zipfel, Peter
(author)
-
Koske, Iris
(author)
-
Nordström, TheréseLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-tno
(author)
-
Riesbeck, KristianLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-kri
(author)
-
Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Journal of Infectious Diseases: Oxford University Press (OUP)210:8, s. 1306-13101537-66130022-1899
Internet link
Find in a library
To the university's database