SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:296a023c-cc5b-4aaa-ad2b-d2fb538c0768"
 

Search: onr:"swepub:oai:lup.lub.lu.se:296a023c-cc5b-4aaa-ad2b-d2fb538c0768" > Treatment of warfar...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Aguilar, Maria I. (author)

Treatment of warfarin-associated intracerebral hemorrhage: Literature review and expert opinion

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:296a023c-cc5b-4aaa-ad2b-d2fb538c0768
  • https://lup.lub.lu.se/record/679249URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Wider use of oral anticoagulants has led to an increasing frequency of warfarin-related intracerebral hemorrhage (ICH). The high early mortality of approximately 50% has remained stable in recent decades. In contrast to spontaneous ICH, the duration of bleeding is, 12 to 24 hours in many patients, offering a longer opportunity for Intervention. Treatment varies widely, and optimal therapy has yet to be defined. An OVID search was conducted from January 1996 to January 2006, combining the terms warfarin or anticoagulation with intracranial hemorrhage or intracerebral hemorrhage. Seven experts on clinical stroke, neurologic intensive care, and hematology were provided with the available information and were asked to independently address 3 clinical scenarios about acute reversal and resumption of anticoagulation in the setting of warfarin-associated ICH. No randomized trials assessing clinical outcomes were found on management of warfarin-associated ICH. All experts agreed that anticoagulation should be urgently reversed, but how to achieve it varied from use of prothrombin complex concentrates only (3 experts) to recombinant factor Vila only (2 experts) to recombinant factor Vila along with fresh frozen plasma (1 expert) and prothrombin complex concentrates or fresh frozen plasma (1 expert). All experts favored resumption of warfarin therapy within 3 to 10 days of ICH in stable patients in whom subsequent anticoagulation is mandatory. No general agreement occurred regarding subsequent anticoagulation of patients with atrial fibrillation who survived warfarin-associated ICH. For warfarin-associated ICH, discontinuing warfarin therapy with administration of vitamin K does not reverse the hemostatic defect for many hours and is inadequate. Reasonable management based on expert opinion includes a wide range of additional measures to reverse anticoagulation in the absence of solid evidence.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hart, Robert G. (author)
  • Kase, Carlos S. (author)
  • Freeman, William D. (author)
  • Hoeben, Maj Barbara J. (author)
  • Garcia, Rosa C. (author)
  • Ansell, Jack E. (author)
  • Mayer, Stephan A. (author)
  • Norrving, BoLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-bno (author)
  • Rosand, Jonathan (author)
  • Steiner, Thorsten (author)
  • Wijdicks, Eelco F. M. (author)
  • Yamaguchi, Takenori (author)
  • Yasaka, Masahiro (author)
  • Neurologi, LundSektion IV (creator_code:org_t)

Related titles

  • In:Mayo Clinic Proceedings82:1, s. 82-920025-6196

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view