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A fibrin biofilm co...
A fibrin biofilm covers blood clots and protects from microbial invasion
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- Macrae, Fraser L. (author)
- University of Leeds
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- Duval, Cédric (author)
- University of Leeds
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- Papareddy, Praveen (author)
- Lund University,Lunds universitet,Host parasite interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Baker, Stephen R. (author)
- University of Leeds
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- Yuldasheva, Nadira (author)
- University of Leeds
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- Kearney, Katherine J. (author)
- University of Leeds
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- McPherson, Helen R. (author)
- University of Leeds
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- Asquith, Nathan (author)
- University of Leeds
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- Konings, Joke (author)
- Maastricht University Medical Centre
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- Casini, Alessandro (author)
- Geneva University Hospital
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- Degen, Jay L. (author)
- Cincinnati Children's Hospital Medical Center
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- Connell, Simon D. (author)
- University of Leeds
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- Philippou, Helen (author)
- University of Leeds
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- Wolberg, Alisa S. (author)
- University of North Carolina
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- Herwald, Heiko (author)
- Lund University,Lunds universitet,Host parasite interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Ariëns, Robert A.S. (author)
- University of Leeds,Maastricht University
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(creator_code:org_t)
- 2018
- 2018
- English 13 s.
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In: Journal of Clinical Investigation. - 0021-9738. ; 128:8, s. 3356-3368
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highly permeable, but the spatial arrangement of the external clot face is unknown. Here we show that fibrin transitioned to the blood-air interface through Langmuir film formation, producing a protective film confining clots in human and mouse models. We demonstrated that only fibrin is required for formation of the film, and that it occurred in vitro and in vivo. The fibrin film connected to the underlying clot network through tethering fibers. It was digested by plasmin, and formation of the film was prevented with surfactants. Functionally, the film retained blood cells and protected against penetration by bacterial pathogens in a murine model of dermal infection. Our data show a remarkable aspect of blood clotting in which fibrin forms a protective film covering the external surface of the clot, defending the organism against microbial invasion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Macrae, Fraser L ...
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Duval, Cédric
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Papareddy, Prave ...
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Baker, Stephen R ...
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Yuldasheva, Nadi ...
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Kearney, Katheri ...
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show more...
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McPherson, Helen ...
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Asquith, Nathan
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Konings, Joke
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Casini, Alessand ...
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Degen, Jay L.
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Connell, Simon D ...
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Philippou, Helen
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Wolberg, Alisa S ...
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Herwald, Heiko
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Ariëns, Robert A ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Journal of Clini ...
- By the university
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Lund University