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Interleukin (IL)-6 ...
Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria
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- Benson, Mikael (author)
- East Hospital, Göteborg, Sweden
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- Jodal, Ulf (author)
- Göteborg University, Sweden
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- Agace, William (author)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Medicinsk mikrobiologi,Mucosal Immunology,Lund University Research Groups,Medical Microbiology,Lund University, Sweden
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- Hellström, Mikael (author)
- Sahlgrenska University Hospital, Göteborg, Sweden
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- Mårild, Staffan (author)
- Sahlgrenska University Hospital, Göteborg, Sweden
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- Rosberg, Sten (author)
- Göteborg University, Sweden
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- Sjöström, Michael (author)
- Umeå University, Sweden
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Wettergren, Björn (author)
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Jönsson, Susanne (author)
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- Svanborg, Catharina (author)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Lund University, Sweden
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(creator_code:org_t)
- Oxford University Press (OUP), 1996
- 1996
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 174:5, s. 1080-1084
- Related links:
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Abstract
Subject headings
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- Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responds were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Benson, Mikael
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Jodal, Ulf
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Agace, William
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Hellström, Mikae ...
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Mårild, Staffan
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Rosberg, Sten
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Sjöström, Michae ...
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Wettergren, Björ ...
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Jönsson, Susanne
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Svanborg, Cathar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Lund University
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Linköping University