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Inherited genetic s...
Inherited genetic susceptibility to multiple myeloma
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2013-11-19
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Springer Science and Business Media LLC,2014
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:2ab5b02b-8b9f-47e2-b020-206b6ff17eec
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https://lup.lub.lu.se/record/4410642URI
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https://doi.org/10.1038/leu.2013.344DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:for swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Johnson, D. C.
(author)
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Weinhold, N.
(author)
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Goldschmidt, H.
(author)
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Landgren, O.
(author)
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Lynch, H. T.
(author)
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Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-khk
(author)
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Houlston, R. S.
(author)
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Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Leukemia: Springer Science and Business Media LLC28:3, s. 518-5241476-55510887-6924
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