Inherited genetic susceptibility to multiple myeloma

Although the familial clustering of multiple myeloma (MM) supports the role of inherited susceptibility, only recently has direct evidence for genetic predisposition been demonstrated. A meta-analysis of two genome-wide association (GWA) studies has identified single-nucleotide polymorphisms (SNPs) localising to a number of genomic regions that are robustly associated with MM risk. In this review, we provide an overview of the evidence supporting a genetic contribution to the predisposition to MM and MGUS (monoclonal gammopathy of unknown significance), and the insight this gives into the biological basis of disease aetiology. We also highlight the promise of future approaches to identify further specific risk factors and their potential clinical utility.

Johnson, D. C. (author)
Weinhold, N. (author)
Goldschmidt, H. (author)
Landgren, O. (author)
Lynch, H. T. (author)
Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-khk (author)
Houlston, R. S. (author)
Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

In:Leukemia: Springer Science and Business Media LLC28:3, s. 518-5241476-55510887-6924

By the author/editor: Morgan, G. J.; Johnson, D. C.; Weinhold, N.; Goldschmidt, H.; Landgren, O.; Lynch, H. T.; show more...; Hemminki, Kari; Houlston, R. S.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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