onr:"swepub:oai:lup.lub.lu.se:2ad795de-7fba-4dfe-8463-7a9c811af836"
Search: onr:"swepub:oai:lup.lub.lu.se:2ad795de-7fba-4dfe-8463-7a9c811af836" > Preoperative and pe...
- 1 of 1
- Previous record
- Next record
- To hitlist
Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion.
- Toller, W (author)
- Heringlake, M (author)
- Guarracino, F (author)
- show more...
- Alvarez, J (author)
- Argyriadou, H (author)
- Ben-Gal, T (author)
- Černý, V (author)
- Cholley, B (author)
- Eremenko, A (author)
- Guerrero-Orriach, J L (author)
- Järvelä, K (author)
- Karanovic, N (author)
- Kivikko, M (author)
- Lahtinen, P (author)
- Lomivorotov, V (author)
- Mehta, R H (author)
- Mušič, Š (author)
- Pollesello, P (author)
- Rex, S (author)
- Riha, H (author)
- Rudiger, A (author)
- Salmenperä, M (author)
- Szudi, L (author)
- Tritapepe, L (author)
- Wyncoll, D (author)
- show less...
- (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
- In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 184, s. 323-336
- Research review (peer-reviewed)
Abstract
Subject headings
Close
- In cardiac surgery, postoperative low cardiac output has been shown to correlate with increased rates of organ failure and mortality. Catecholamines have been the standard therapy for many years, although they carry substantial risk for adverse cardiac and systemic effects, and have been reported to be associated with increased mortality. On the other hand, the calcium sensitiser and potassium channel opener levosimendan has been shown to improve cardiac function with no imbalance in oxygen consumption, and to have protective effects in other organs. Numerous clinical trials have indicated favourable cardiac and non-cardiac effects of preoperative and perioperative administration of levosimendan. A panel of 27 experts from 18 countries has now reviewed the literature on the use of levosimendan in on-pump and off-pump coronary artery bypass grafting and in heart valve surgery. This panel discussed the published evidence in these various settings, and agreed to vote on a set of questions related to the cardioprotective effects of levosimendan when administered preoperatively, with the purpose of reaching a consensus on which patients could benefit from the preoperative use of levosimendan and in which kind of procedures, and at which doses and timing should levosimendan be administered. Here, we present a systematic review of the literature to report on the completed and ongoing studies on levosimendan, including the newly commenced LEVO-CTS phase III study (NCT02025621), and on the consensus reached on the recommendations proposed for the use of preoperative levosimendan.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
- International Journal of Cardiology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Toller, W
- Heringlake, M
- Guarracino, F
- Algotsson, Lars
- Alvarez, J
- Argyriadou, H
- show more...
- Ben-Gal, T
- Černý, V
- Cholley, B
- Eremenko, A
- Guerrero-Orriach ...
- Järvelä, K
- Karanovic, N
- Kivikko, M
- Lahtinen, P
- Lomivorotov, V
- Mehta, R H
- Mušič, Š
- Pollesello, P
- Rex, S
- Riha, H
- Rudiger, A
- Salmenperä, M
- Szudi, L
- Tritapepe, L
- Wyncoll, D
- Öwall, A
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- International Jo ...
- By the university
- Lund University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
