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MiR-184 regulates p...
MiR-184 regulates pancreatic β-cell function according to glucose metabolism.
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Tattikota, Sudhir G (författare)
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Rathjen, Thomas (författare)
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Hausser, Jean (författare)
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visa fler...
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Khedkar, Aditya (författare)
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Kabra, Uma D (författare)
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Pandey, Varun K (författare)
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Sury, Matthias (författare)
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Wessels, Hans-Hermann (författare)
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- Mollet, Ines (författare)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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- Eliasson, Lena (författare)
- Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups
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Selbach, Matthias (författare)
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Zinzen, Robert P (författare)
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Zavolan, Mihaela (författare)
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Kadener, Sebastian (författare)
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Tschöp, Matthias (författare)
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Jastroch, Martin (författare)
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Friedländer, Marc R (författare)
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Poy, Matthew N (författare)
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(creator_code:org_t)
- 2015
- 2015
- Engelska.
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Ingår i: Journal of Biological Chemistry. - 1083-351X. ; 290:33, s. 20284-20294
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Abstract
Ämnesord
Stäng
- In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however the pathways governing this adaptive response are not entirely established. While the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes their function in cellular stress responses. We recently showed that miR-184, an abundant miRNA in the β-cell, regulates compensatory proliferation and secretion during insulin resistance. Consistent with previous studies showing miR-184 suppresses insulin release, expression of this miRNA was increased in islets after fasting, demonstrating an active role in the β-cell as glucose levels lower and the insulin demand ceases. Additionally, miR-184 was negatively regulated upon administration of a sucrose-rich diet in Drosophila demonstrating strong conservation of this pathway through evolution. Furthermore, miR-184 and its target Argonaute2 (Ago2) remained inversely correlated as concentrations of extracellular glucose increased, underlining a functional relationship between this miRNA and its targets. Lastly, restoration of Ago2 in the presence of miR-184 rescued suppression of miR-375-targeted genes suggesting these genes act in a coordinated manner during changes in the metabolic context. Together, these results highlight the adaptive role of miR-184 according to glucose metabolism and suggest the regulatory role of this miRNA in energy homeostasis is highly conserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Tattikota, Sudhi ...
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Rathjen, Thomas
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Hausser, Jean
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Khedkar, Aditya
-
Kabra, Uma D
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Pandey, Varun K
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visa fler...
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Sury, Matthias
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Wessels, Hans-He ...
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Mollet, Ines
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Eliasson, Lena
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Selbach, Matthia ...
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Zinzen, Robert P
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Zavolan, Mihaela
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Kadener, Sebasti ...
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Tschöp, Matthias
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Jastroch, Martin
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Friedländer, Mar ...
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Poy, Matthew N
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Journal of Biolo ...
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Lunds universitet