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Frataxin deficiency...
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Ristow, MichaelFree University of Berlin,German Institute of Human Nutrition
(author)
Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass
- Article/chapterEnglish2003
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:2b9eca7a-c0c6-478f-93fa-832730d70db2
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https://lup.lub.lu.se/record/2b9eca7a-c0c6-478f-93fa-832730d70db2URI
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https://doi.org/10.1172/JCI18107DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing β cells. We have disrupted expression of the mitochondrial protein frataxin selectively in pancreatic β cells. Mice were born healthy but subsequently developed impaired glucose tolerance progressing to overt diabetes mellitus. These observations were explained by impairment of insulin secretion due to a loss of β cell mass in knockout animals. This phenotype was preceded by elevated levels of reactive oxygen species in knockout islets, an increased frequency of apoptosis, and a decreased number of proliferating β cells. Hence, disruption of the frataxin gene in pancreatic β cells causes diabetes following cellular growth arrest and apoptosis, paralleled by an increase in reactive oxygen species in islets. These observations might provide insight into the deterioration of β cell function observed in different subtypes of diabetes in humans.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Mulder, HindrikLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)medk-hmu
(author)
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Pomplun, DoreenFree University of Berlin,German Institute of Human Nutrition
(author)
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Schulz, Tim J.Free University of Berlin,German Institute of Human Nutrition
(author)
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Müller-Schmehl, KatrinGerman Institute of Human Nutrition
(author)
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Krause, AnjaGerman Institute of Human Nutrition
(author)
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Fex, MalinLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)medk-mf0
(author)
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Puccio, HélèneIGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire
(author)
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Müller, JörgMagnettech GmbH
(author)
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Isken, FrankGerman Institute of Human Nutrition,Free University of Berlin
(author)
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Spranger, JoachimFree University of Berlin,German Institute of Human Nutrition
(author)
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Müller-Wieland, DirkGerman Diabetes Research Institute
(author)
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Magnuson, Mark A.Vanderbilt University
(author)
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Möhlig, MatthiasGerman Institute of Human Nutrition,Free University of Berlin
(author)
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Koenig, MichelIGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire
(author)
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Pfeiffer, Andreas F.H.German Institute of Human Nutrition,Free University of Berlin
(author)
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Free University of BerlinGerman Institute of Human Nutrition
(creator_code:org_t)
Related titles
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In:Journal of Clinical Investigation112:4, s. 527-5340021-9738
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Ristow, Michael
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Mulder, Hindrik
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Pomplun, Doreen
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Schulz, Tim J.
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Müller-Schmehl, ...
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Krause, Anja
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Fex, Malin
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Puccio, Hélène
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Müller, Jörg
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Isken, Frank
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Spranger, Joachi ...
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Müller-Wieland, ...
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Magnuson, Mark A ...
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Möhlig, Matthias
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Koenig, Michel
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Pfeiffer, Andrea ...
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Lund University