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  • Ristow, MichaelFree University of Berlin,German Institute of Human Nutrition (author)

Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass

  • Article/chapterEnglish2003

Publisher, publication year, extent ...

  • 2003

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  • LIBRIS-ID:oai:lup.lub.lu.se:2b9eca7a-c0c6-478f-93fa-832730d70db2
  • https://lup.lub.lu.se/record/2b9eca7a-c0c6-478f-93fa-832730d70db2URI
  • https://doi.org/10.1172/JCI18107DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing β cells. We have disrupted expression of the mitochondrial protein frataxin selectively in pancreatic β cells. Mice were born healthy but subsequently developed impaired glucose tolerance progressing to overt diabetes mellitus. These observations were explained by impairment of insulin secretion due to a loss of β cell mass in knockout animals. This phenotype was preceded by elevated levels of reactive oxygen species in knockout islets, an increased frequency of apoptosis, and a decreased number of proliferating β cells. Hence, disruption of the frataxin gene in pancreatic β cells causes diabetes following cellular growth arrest and apoptosis, paralleled by an increase in reactive oxygen species in islets. These observations might provide insight into the deterioration of β cell function observed in different subtypes of diabetes in humans.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mulder, HindrikLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)medk-hmu (author)
  • Pomplun, DoreenFree University of Berlin,German Institute of Human Nutrition (author)
  • Schulz, Tim J.Free University of Berlin,German Institute of Human Nutrition (author)
  • Müller-Schmehl, KatrinGerman Institute of Human Nutrition (author)
  • Krause, AnjaGerman Institute of Human Nutrition (author)
  • Fex, MalinLund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups(Swepub:lu)medk-mf0 (author)
  • Puccio, HélèneIGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire (author)
  • Müller, JörgMagnettech GmbH (author)
  • Isken, FrankGerman Institute of Human Nutrition,Free University of Berlin (author)
  • Spranger, JoachimFree University of Berlin,German Institute of Human Nutrition (author)
  • Müller-Wieland, DirkGerman Diabetes Research Institute (author)
  • Magnuson, Mark A.Vanderbilt University (author)
  • Möhlig, MatthiasGerman Institute of Human Nutrition,Free University of Berlin (author)
  • Koenig, MichelIGBMC, Institut de Génétique et de Biologie Moléculaire et Cellulaire (author)
  • Pfeiffer, Andreas F.H.German Institute of Human Nutrition,Free University of Berlin (author)
  • Free University of BerlinGerman Institute of Human Nutrition (creator_code:org_t)

Related titles

  • In:Journal of Clinical Investigation112:4, s. 527-5340021-9738

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