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- Drott, Carl Johan,1984-Uppsala universitet,Institutionen för medicinsk cellbiologi,Per-Ola Carlsson (author)
CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- Elsevier BV,2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-421461
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421461URI
- https://doi.org/10.1016/j.peptides.2020.170431DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Cocaine- and amphetamine-regulated transcript (CART) is a neurotransmitter and hormone, involved in the regulation of e.g. food intake, body weight, reward and addiction, and stress response. CART has also been found to affect insulin secretion and beta cell morphology, both in vivo and in vitro. Furthermore, CART affects regulation of the cardiovascular system and helps to modulate vascular tone. The present study evaluated the local effect of CART on the pancreatic and islet circulation and function. CART (25 µg/h) or saline, combinations of CART and endothelin-A receptor antagonist (BQ123; 100 µg/kg), and glucose (2 g/kg) were intravenously infused in Sprague Dawley rats followed by blood flow measurements using a microsphere technique. Separately, CART-infused animals underwent an intravenous glucose tolerance test (ivGTT). The direct effect of CART on insulin release was investigated using isolated islets from Sprague Dawley rats. CART reduced islet blood flow, without reduction in total pancreatic blood flow. The normal glucose-induced islet blood flow increase was diminished by CART, albeit still present. Simultaneously, CART had no effect on systemic-, intestinal- or renal blood flow. The endothelin-A receptor antagonist BQ123 together with CART had no pancreatic vascular effects. We found that CART has pronounced vascular constrictive actions restricted to the pancreatic islet circulation but had no effect on insulin release neither in vivo nor in vitro. The mechanisms behind the vascular effects are still unknown, but may reflect a direct action on pancreatic blood vessels.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- CART
- pancreatic islets
- blood flow
- vascular
- Medical Cell Biology
- Medicinsk cellbiologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Norman, DanielUppsala universitet,Institutionen för medicinsk cellbiologi,Per-Ola Carlsson(Swepub:uu)danno132 (author)
- Espes, Daniel,1985-Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin,Per-Ola Carlsson(Swepub:uu)danes392 (author)
- Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)
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- In:Peptides: Elsevier BV1350196-97811873-5169
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