Pretreatment with MK-801 or the lazaroid U-83836E does not enhance striatal graft survival

Mundt-Petersen, Ulrika (author): Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Wallenberg Neurocentrum, Lund,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Wallenberg Neuroscience Centre, Lund,Lund University Research Groups

Karlsson, Jenny (author): Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Wallenberg Neurocentrum, Lund,Department of Experimental Medical Science,Faculty of Medicine,Wallenberg Neuroscience Centre, Lund

Brundin, Patrik (author): Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine

(creator_code:org_t)

2017-06-22
2000
English.
In: Cell Transplantation. - : SAGE Publications. - 0963-6897 .- 1555-3892. ; 9:1, s. 73-78

Related links:: http://dx.doi.org/10...; show more...; https://journals.sag...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

A large proportion of grafted striatal neurons die, and mechanisms by which they succumb may involve excitotoxicity and oxidative stress. We investigated the effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate (MK-801) and lipid peroxidation inhibitor lazaroid U-83836E on the survival of transplanted striatal neurons. Neither compound increased the survival of grafts, suggesting that NMDA-related excitotoxicity or oxidative stress may not be primary mediators of cell death in striatal grafts.

By the author/editor: Mundt-Petersen, ...; Karlsson, Jenny; Kaminski Schierl ...; Brundin, Patrik

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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