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Metabolomic analysi...
Metabolomic analysis of male combat veterans with post traumatic stress disorder
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- Mellon, Synthia H. (author)
- University of California, San Francisco
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- Bersani, F. Saverio (author)
- University of California, San Francisco
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- Lindqvist, Daniel (author)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för klinisk suicidforskning,Forskargrupper vid Lunds universitet,Enheten för Biologisk Psykiatri och Precisionspsykiatri,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for clinical suicide research,Lund University Research Groups,Unit for Biological and Precision Psychiatry,University of California, San Francisco
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- Hammamieh, Rasha (author)
- U.S. Army Center for Environmental Health Research
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- Donohue, Duncan (author)
- U.S. Army Center for Environmental Health Research
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- Dean, Kelsey (author)
- Harvard University
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- Jett, Marti (author)
- U.S. Army Center for Environmental Health Research
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- Yehuda, Rachel (author)
- Icahn School of Medicine at Mount Sinai
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- Flory, Janine (author)
- Icahn School of Medicine at Mount Sinai
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- Reus, Victor I. (author)
- University of California, San Francisco
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- Bierer, Linda M. (author)
- Icahn School of Medicine at Mount Sinai,Veterans Health Administration
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- Makotkine, Iouri (author)
- Icahn School of Medicine at Mount Sinai
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- Amara, Duna Abu (author)
- New York University
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- Haase, Clare Henn (author)
- New York University
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- Coy, Michelle (author)
- University of California, San Francisco
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- Doyle, Francis J. (author)
- Harvard University
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- Marmar, Charles (author)
- New York University,NYU Langone
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- Wolkowitz, Owen M. (author)
- University of California, San Francisco
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(creator_code:org_t)
- 2019-03-18
- 2019
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:3
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Abstract
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- Posttraumatic stress disorder (PTSD) is associated with impaired major domains of psychology and behavior. Individuals with PTSD also have increased co-morbidity with several serious medical conditions, including autoimmune diseases, cardiovascular disease, and diabetes, raising the possibility that systemic pathology associated with PTSD might be identified by metabolomic analysis of blood. We sought to identify metabolites that are altered in male combat veterans with PTSD. In this case-control study, we compared metabolomic profiles from age-matched male combat trauma-exposed veterans from the Iraq and Afghanistan conflicts with PTSD (n = 52) and without PTSD (n = 51) (‘Discovery group’). An additional group of 31 PTSD-positive and 31 PTSD-negative male combat-exposed veterans was used for validation of these findings (‘Test group’). Plasma metabolite profiles were measured in all subjects using ultrahigh performance liquid chromatography/tandem mass spectrometry and gas chromatography/mass spectrometry. We identified key differences between PTSD subjects and controls in pathways related to glycolysis and fatty acid uptake and metabolism in the initial ‘Discovery group’, consistent with mitochondrial alterations or dysfunction, which were also confirmed in the ‘Test group’. Other pathways related to urea cycle and amino acid metabolism were different between PTSD subjects and controls in the ‘Discovery’ but not in the smaller ‘Test’ group. These metabolic differences were not explained by comorbid major depression, body mass index, blood glucose, hemoglobin A1c, smoking, or use of analgesics, antidepressants, statins, or anti-inflammatories. These data show replicable, wide-ranging changes in the metabolic profile of combat-exposed males with PTSD, with a suggestion of mitochondrial alterations or dysfunction, that may contribute to the behavioral and somatic phenotypes associated with this disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Mellon, Synthia ...
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Bersani, F. Save ...
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Lindqvist, Danie ...
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Hammamieh, Rasha
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Donohue, Duncan
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Dean, Kelsey
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show more...
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Jett, Marti
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Yehuda, Rachel
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Flory, Janine
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Reus, Victor I.
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Bierer, Linda M.
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Makotkine, Iouri
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Amara, Duna Abu
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Haase, Clare Hen ...
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Coy, Michelle
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Doyle, Francis J ...
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Marmar, Charles
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Wolkowitz, Owen ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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PLoS ONE
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Lund University