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Impact of insuffici...
Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions
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- Tsereteli, Neli (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Vallat, Raphael (author)
- University of California, Berkeley
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- Fernandez-Tajes, Juan (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Delahanty, Linda M. (author)
- Massachusetts General Hospital
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- Ordovas, Jose M. (author)
- Tufts University,Madrid Institute For Advanced Studies (IMDEA) Food Institute
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- Drew, David A. (author)
- Massachusetts General Hospital
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- Valdes, Ana M. (author)
- Nottingham University Hospitals NHS Trust
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- Segata, Nicola (author)
- European Institute of Oncology,University of Trento
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- Chan, Andrew T. (author)
- Massachusetts General Hospital
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Wolf, Jonathan (author)
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- Berry, Sarah E. (author)
- King's College London
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- Walker, Matthew P. (author)
- University of California, Berkeley
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- Spector, Timothy D. (author)
- King's College London
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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(creator_code:org_t)
- 2021-11-30
- 2022
- English.
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In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 65:2, s. 356-365
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Abstract
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- Aims/hypothesis: Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual’s sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning. Methods: Healthy adults’ data (N = 953 [41% twins]) were analysed from the PREDICT dietary intervention trial. Participants consumed isoenergetic standardised meals over 2 weeks in the clinic and at home. Actigraphy was used to assess sleep variables (duration, efficiency, timing) and continuous glucose monitors were used to measure glycaemic variation (>8000 meals). Results: Sleep variables were significantly associated with postprandial glycaemic control (2 h incremental AUC), at both between- and within-person levels. Sleep period time interacted with meal type, with a smaller effect of poor sleep on postprandial blood glucose levels when high-carbohydrate (low fat/protein) (pinteraction = 0.02) and high-fat (pinteraction = 0.03) breakfasts were consumed compared with a reference 75 g OGTT. Within-person sleep period time had a similar interaction (high carbohydrate: pinteraction = 0.001, high fat: pinteraction = 0.02). Within- and between-person sleep efficiency were significantly associated with lower postprandial blood glucose levels irrespective of meal type (both p < 0.03). Later sleep midpoint (time deviation from midnight) was found to be significantly associated with higher postprandial glucose, in both between-person and within-person comparisons (p = 0.035 and p = 0.051, respectively). Conclusions/interpretation: Poor sleep efficiency and later bedtime routines are associated with more pronounced postprandial glycaemic responses to breakfast the following morning. A person’s deviation from their usual sleep pattern was also associated with poorer postprandial glycaemic control. These findings underscore sleep as a modifiable, non-pharmacological therapeutic target for the optimal regulation of human metabolic health. Trial registrationClinicalTrials.gov NCT03479866. Graphical abstract: [Figure not available: see fulltext.]
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Diet
- Metabolic health
- Person-centring
- Postprandial glucose
- Sleep
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tsereteli, Neli
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Vallat, Raphael
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Fernandez-Tajes, ...
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Delahanty, Linda ...
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Ordovas, Jose M.
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Drew, David A.
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Valdes, Ana M.
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Segata, Nicola
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Chan, Andrew T.
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Wolf, Jonathan
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Berry, Sarah E.
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Walker, Matthew ...
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Spector, Timothy ...
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Franks, Paul W.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Diabetologia
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Lund University