Search: onr:"swepub:oai:lup.lub.lu.se:2cfafd80-012b-4bfd-aeb2-954ad70ef206" >
Changes in insulin-...
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Bergstedt, K.Skåne University Hospital,Lund University
(author)
Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat : Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1
- Article/chapterEnglish1993
Publisher, publication year, extent ...
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2016-06-28
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SAGE Publications,1993
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4 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:2cfafd80-012b-4bfd-aeb2-954ad70ef206
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https://lup.lub.lu.se/record/2cfafd80-012b-4bfd-aeb2-954ad70ef206URI
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https://doi.org/10.1038/jcbfm.1993.112DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Binding of 125I-insulin-like growth factor-1 (125I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA1 and CA3 regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1 receptor may be interrupted.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wieloch, T.Lund University,Lunds universitet,Laboratory for Experimental Brain Research,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)efor-twi
(author)
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Skåne University HospitalLund University
(creator_code:org_t)
Related titles
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In:Journal of Cerebral Blood Flow and Metabolism: SAGE Publications13:5, s. 895-8980271-678X1559-7016
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