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Reducing Initial Lo...
Reducing Initial Loss to Follow-up Among People With Bacteriologically Confirmed Tuberculosis : LINKEDin, a Quasi-experimental Study in South Africa
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- Meehan, Sue Ann (author)
- Stellenbosch University
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- Hesseling, Anneke C. (author)
- Stellenbosch University
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- Boulle, Andrew (author)
- University of Cape Town
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Chetty, Jolene (author)
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Connell, Lucy (author)
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Dlamini-Miti, Nomthandazo J. (author)
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- Dunbar, Rory (author)
- Stellenbosch University
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- Preez, Karen Du (author)
- Stellenbosch University
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- George, Gavin (author)
- Lund University,Lunds universitet,Socialmedicin och global hälsa,Forskargrupper vid Lunds universitet,Social Medicine and Global Health,Lund University Research Groups,University of KwaZulu-Natal
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- Hoddinott, Graeme (author)
- Stellenbosch University
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Jennings, Karen (author)
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- Marx, Florian M. (author)
- Stellenbosch University,University Hospital Heidelberg
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Mudaly, Vanessa (author)
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- Naidoo, Pren (author)
- Bill & Melinda Gates Foundation
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Ndlovu, Neo (author)
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Ngozo, Jacqueline (author)
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- Smith, Mariette (author)
- University of Cape Town
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- Strauss, Michael (author)
- University of KwaZulu-Natal
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- Tanna, Gaurang (author)
- Bill & Melinda Gates Foundation
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- Vanqa, Nosivuyile (author)
- Stellenbosch University
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- von Delft, Arne (author)
- University of Cape Town
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- Osman, Muhammad (author)
- University of Greenwich,Stellenbosch University
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Open Forum Infectious Diseases. - 2328-8957. ; 11:1
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
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- Every person diagnosed with tuberculosis (TB) needs to initiate treatment. The World Health Organization estimated that 61% of people who developed TB in 2021 were included in a TB treatment registration system. Initial loss to follow-up (ILTFU) is the loss of persons to care between diagnosis and treatment initiation/registration. LINKEDin, a quasi-experimental study, evaluated the effect of 2 interventions (hospital recording and an alert-and-response patient management intervention) in 6 subdistricts across 3 high–TB burden provinces of South Africa. Using integrated electronic reports, we identified all persons diagnosed with TB (Xpert MTB/ RIF positive) in the hospital and at primary health care facilities. We prospectively determined linkage to care at 30 days after TB diagnosis. We calculated the risk of ILTFU during the baseline and intervention periods and the relative risk reduction in ILTFU between these periods. We found a relative reduction in ILTFU of 42.4% (95% CI, 28.5%–53.7%) in KwaZulu Natal (KZN) and 22.3% (95% CI, 13.3%–30.4%) in the Western Cape (WC), with no significant change in Gauteng. In KZN and the WC, the relative reduction in ILTFU appeared greater in subdistricts where the alert-and-response patient management intervention was implemented (KZN: 49.3%; 95% CI, 32.4%–62%; vs 32.2%; 95% CI, 5.4%–51.4%; and WC: 34.2%; 95% CI, 20.9%–45.3%; vs 13.4%; 95% CI, 0.7%–24.4%). We reported a notable reduction in ILTFU in 2 provinces using existing routine health service data and applying a simple intervention to trace and recall those not linked to care. TB programs need to consider ILTFU a priority and develop interventions specific to their context to ensure improved linkage to care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- initial loss to follow-up
- tuberculosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Meehan, Sue Ann
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Hesseling, Annek ...
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Boulle, Andrew
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Chetty, Jolene
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Connell, Lucy
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Dlamini-Miti, No ...
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show more...
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Dunbar, Rory
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Preez, Karen Du
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George, Gavin
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Hoddinott, Graem ...
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Jennings, Karen
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Marx, Florian M.
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Mudaly, Vanessa
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Naidoo, Pren
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Ndlovu, Neo
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Ngozo, Jacquelin ...
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Smith, Mariette
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Strauss, Michael
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Tanna, Gaurang
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Vanqa, Nosivuyil ...
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von Delft, Arne
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Osman, Muhammad
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Open Forum Infec ...
- By the university
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Lund University