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Unfolding the Medial Temporal Lobe Cortex to Characterize Neurodegeneration Due to Alzheimer’s Disease Pathology Using Ex vivo Imaging

Ravikumar, Sadhana (author)
University of Pennsylvania
Wisse, Laura (author)
Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
Lim, Sydney (author)
University of Pennsylvania
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Irwin, David (author)
University of Pennsylvania
Ittyerah, Ranjit (author)
University of Pennsylvania
Xie, Long (author)
University of Pennsylvania
Das, Sandhitsu R. (author)
University of Pennsylvania
Lee, Edward (author)
University of Pennsylvania
Tisdall, M. Dylan (author)
University of Pennsylvania
Prabhakaran, Karthik (author)
University of Pennsylvania
Detre, John (author)
University of Pennsylvania
Mizsei, Gabor (author)
University of Pennsylvania
Trojanowski, John Q. (author)
University of Pennsylvania
Robinson, John (author)
University of Pennsylvania
Schuck, Theresa (author)
University of Pennsylvania
Grossman, Murray (author)
University of Pennsylvania
Artacho-Pérula, Emilio (author)
University of Castilla La Mancha
de Onzoño Martin, Maria Mercedes Iñiguez (author)
University of Castilla La Mancha
del Mar Arroyo Jiménez, María (author)
University of Castilla La Mancha
Muñoz, Monica (author)
University of Castilla La Mancha
Romero, Francisco Javier Molina (author)
University of Castilla La Mancha
del Pilar Marcos Rabal, Maria (author)
University of Castilla La Mancha
Sánchez, Sandra Cebada (author)
University of Castilla La Mancha
González, José Carlos Delgado (author)
University of Castilla La Mancha
de la Rosa Prieto, Carlos (author)
University of Castilla La Mancha
Parada, Marta Córcoles (author)
University of Castilla La Mancha
Wolk, David (author)
University of Pennsylvania
Insausti, Ricardo (author)
University of Castilla La Mancha
Yushkevich, Paul (author)
University of Pennsylvania
Abdulkadir, Ahmed (editor)
Kia, Seyed Mostafa (editor)
Habes, Mohamad (editor)
Kumar, Vinod (editor)
Rondina, Jane Maryam (editor)
Tax, Chantal (editor)
Wolfers, Thomas (editor)
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 (creator_code:org_t)
2021-09-21
2021
English 10 s.
In: Machine Learning in Clinical Neuroimaging - 4th International Workshop, MLCN 2021, Held in Conjunction with MICCAI 2021, Proceedings. - Cham : Springer International Publishing. - 0302-9743 .- 1611-3349. - 9783030875855 ; 13001 LNCS, s. 3-12
Related links:
http://dx.doi.org/10...
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  • Conference paper (peer-reviewed)
Abstract Subject headings
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  • Neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s Disease (AD). In this work, we investigate the relationship between MTL morphometry features derived from high-resolution ex vivo imaging and histology-based measures of NFT pathology using a topological unfolding framework applied to a dataset of 18 human postmortem MTL specimens. The MTL has a complex 3D topography and exhibits a high degree of inter-subject variability in cortical folding patterns which poses a significant challenge for volumetric registration methods typically used during MRI template construction. By unfolding the MTL cortex, the proposed framework explicitly accounts for the sheet-like geometry of the MTL cortex and provides a two-dimensional reference coordinate space which can be used to implicitly register cortical folding patterns across specimens based on distance along the cortex despite large anatomical variability. Leveraging this framework in a subset of 15 specimens, we characterize the associations between NFTs and morphological features such as cortical thickness and surface curvature and identify regions in the MTL where patterns of atrophy are strongly correlated with NFT pathology.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Image Processing (hsv//eng)

Keyword

Cortical unfolding
Ex vivo MRI
Medial temporal lobe

Publication and Content Type

kon (subject category)
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