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  • Ravikumar, SadhanaUniversity of Pennsylvania (author)

Unfolding the Medial Temporal Lobe Cortex to Characterize Neurodegeneration Due to Alzheimer’s Disease Pathology Using Ex vivo Imaging

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-09-21
  • Cham :Springer International Publishing,2021
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:2daeb4f1-bd4a-4912-a8ee-622d9316740d
  • https://lup.lub.lu.se/record/2daeb4f1-bd4a-4912-a8ee-622d9316740dURI
  • https://doi.org/10.1007/978-3-030-87586-2_1DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:kon swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change associated with Alzheimer’s Disease (AD). In this work, we investigate the relationship between MTL morphometry features derived from high-resolution ex vivo imaging and histology-based measures of NFT pathology using a topological unfolding framework applied to a dataset of 18 human postmortem MTL specimens. The MTL has a complex 3D topography and exhibits a high degree of inter-subject variability in cortical folding patterns which poses a significant challenge for volumetric registration methods typically used during MRI template construction. By unfolding the MTL cortex, the proposed framework explicitly accounts for the sheet-like geometry of the MTL cortex and provides a two-dimensional reference coordinate space which can be used to implicitly register cortical folding patterns across specimens based on distance along the cortex despite large anatomical variability. Leveraging this framework in a subset of 15 specimens, we characterize the associations between NFTs and morphological features such as cortical thickness and surface curvature and identify regions in the MTL where patterns of atrophy are strongly correlated with NFT pathology.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wisse, LauraLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)la3343wi (author)
  • Lim, SydneyUniversity of Pennsylvania (author)
  • Irwin, DavidUniversity of Pennsylvania (author)
  • Ittyerah, RanjitUniversity of Pennsylvania (author)
  • Xie, LongUniversity of Pennsylvania (author)
  • Das, Sandhitsu R.University of Pennsylvania (author)
  • Lee, EdwardUniversity of Pennsylvania (author)
  • Tisdall, M. DylanUniversity of Pennsylvania (author)
  • Prabhakaran, KarthikUniversity of Pennsylvania (author)
  • Detre, JohnUniversity of Pennsylvania (author)
  • Mizsei, GaborUniversity of Pennsylvania (author)
  • Trojanowski, John Q.University of Pennsylvania (author)
  • Robinson, JohnUniversity of Pennsylvania (author)
  • Schuck, TheresaUniversity of Pennsylvania (author)
  • Grossman, MurrayUniversity of Pennsylvania (author)
  • Artacho-Pérula, EmilioUniversity of Castilla La Mancha (author)
  • de Onzoño Martin, Maria Mercedes IñiguezUniversity of Castilla La Mancha (author)
  • del Mar Arroyo Jiménez, MaríaUniversity of Castilla La Mancha (author)
  • Muñoz, MonicaUniversity of Castilla La Mancha (author)
  • Romero, Francisco Javier MolinaUniversity of Castilla La Mancha (author)
  • del Pilar Marcos Rabal, MariaUniversity of Castilla La Mancha (author)
  • Sánchez, Sandra CebadaUniversity of Castilla La Mancha (author)
  • González, José Carlos DelgadoUniversity of Castilla La Mancha (author)
  • de la Rosa Prieto, CarlosUniversity of Castilla La Mancha (author)
  • Parada, Marta CórcolesUniversity of Castilla La Mancha (author)
  • Wolk, DavidUniversity of Pennsylvania (author)
  • Insausti, RicardoUniversity of Castilla La Mancha (author)
  • Yushkevich, PaulUniversity of Pennsylvania (author)
  • Abdulkadir, Ahmed (editor)
  • Kia, Seyed Mostafa (editor)
  • Habes, Mohamad (editor)
  • Kumar, Vinod (editor)
  • Rondina, Jane Maryam (editor)
  • Tax, Chantal (editor)
  • Wolfers, Thomas (editor)
  • University of PennsylvaniaDiagnostisk radiologi, Lund (creator_code:org_t)

Related titles

  • In:Machine Learning in Clinical Neuroimaging - 4th International Workshop, MLCN 2021, Held in Conjunction with MICCAI 2021, ProceedingsCham : Springer International Publishing13001 LNCS, s. 3-120302-97431611-33499783030875855

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