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A Systematic Review...
A Systematic Review of Heterogeneity in Outcome Definition and Reporting in Localised Renal Cancer
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- Beyer, Katharina (author)
- King's College London
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- Widdershoven, Christiaan (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Wintner, Lisa M. (author)
- Medical University of Innsbruck
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- Dabestani, Saeed (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups,Central Hospital Kristianstad
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- Marconi, Lorenzo (author)
- University Hospital of Coimbra
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- Moss, Charlotte (author)
- King's College London
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- Kinsella, Netty (author)
- Royal Marsden Hospital, London,King's College London
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- Yuan, Yuhong (author)
- McMaster University
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- Giles, Rachel H. (author)
- International Kidney Cancer Coalition (IKCC)
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- Barod, Ravi (author)
- Royal Free Hospital
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- Van Hemelrijck, Mieke (author)
- King's College London
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- Bex, Axel (author)
- Royal Free Hospital,Medical University of Innsbruck
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- Zondervan, Patricia (author)
- Medical University of Innsbruck
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- MacLennan, Steven (author)
- University of Aberdeen
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English 11 s.
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In: European Urology Open Science. - : Elsevier BV. - 2666-1691 .- 2666-1683. ; 48, s. 1-11
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Abstract
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- Context: Outcomes in renal cell carcinoma (RCC) are reported inconsistently, with variability in definitions and measurement. Hence, it is difficult to compare intervention effectiveness and synthesise outcomes for systematic reviews and to create clinical practice guidelines. This uncertainty in the evidence makes it difficult to guide patient-clinician decision-making. One solution is a core outcome set (COS): an agreed minimum set of outcomes. Objective: To describe outcome reporting, definitions, and measurement heterogeneity as the first stage in co-creating a COS for localised renal cancer. Evidence acquisition: We systematically reviewed outcome reporting heterogeneity in effectiveness trials and observational studies in localised RCC. In total, 2822 studies (randomised controlled trials, cohort studies, case-control studies, systematic reviews) up to June 2020 meeting our inclusion criteria were identified. Abstracts and full texts were screened independently by two reviewers; in cases of disagreement, a third reviewer arbitrated. Data extractions were double-checked. Evidence synthesis: We included 149 studies and found that there was inconsistency in which outcomes were reported across studies and variability in the definitions used for outcomes that were conceptually the same. We structured our analysis using the outcome classification taxonomy proposed by Dodd et al. Outcomes linked to adverse events (eg, bleeding, outcomes linked to surgery) and renal injury outcomes (reduced renal function) were reported most commonly. Outcomes related to deaths from any cause and from cancer were reported in 44% and 25% of studies, respectively, although the time point for measurement and the analysis methods were inconsistent. Outcomes linked to life impact (eg, global quality of life) were reported least often. Clinician-reported outcomes are more frequently reported than patient-reported outcomes in the renal cancer literature. Conclusions: This systematic review underscores the heterogeneity of outcome reporting, definitions, and measurement in research on localised renal cancer. It catalogues the variety of outcomes and serves as a first step towards the development of a COS for localised renal cancer. Patient summary: We reviewed studies on localised kidney cancer and found that multiple terms and definitions have been used to describe outcomes. These are not defined consistently, and often not defined at all. Our review is the first phase in developing a core outcome set to allow better comparisons of studies to improve medical care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Barriers
- Facilitators
- Oncology
- Patient decision-making
- Renal cell carcinoma
- Treatment choice
- Treatment selection
Publication and Content Type
- for (subject category)
- ref (subject category)
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- By the author/editor
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Beyer, Katharina
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Widdershoven, Ch ...
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Wintner, Lisa M.
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Dabestani, Saeed
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Marconi, Lorenzo
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Moss, Charlotte
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Kinsella, Netty
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Yuan, Yuhong
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Giles, Rachel H.
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Barod, Ravi
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Van Hemelrijck, ...
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Bex, Axel
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Zondervan, Patri ...
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MacLennan, Steve ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Urology ...
- By the university
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Lund University