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Sjöblom, K GSkåne University Hospital
(author)
Factors related to the progression of joint destruction in rheumatoid arthritis.
- Article/chapterEnglish1984
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LIBRIS-ID:oai:lup.lub.lu.se:2e849bac-23a0-4fa3-b3d5-666c1b57508e
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https://lup.lub.lu.se/record/2e849bac-23a0-4fa3-b3d5-666c1b57508eURI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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In 103 (M=25, F=78) of 150 consecutive RA patients, values of the following variables were obtained at the start and end of a 2-year follow-up period: radiographic destruction score of hands and feet according to Larsen (Larsen index), Ritchie index, B-hemoglobin, ESR and plasma proteins (α1-antitrypsin, ceruloplasmin, CRP, fibrinogen, haptoglobin, orosomucoid, IgA, IgG, IgM, C3 and C4). 60% of the values of ΔLI (final minus initial value of Larsen index) were significantly larger than zero (11-44 units, p<0.05). ΔLI was larger in females than in males (p=0.11). Comparing women with duration of disease (DoD) 1-6 years versus 7-52 years, ΔLI was larger in the former group (p=0.005). Comparing women with the largest ΔLI (19-44 units) with the remainder ones (ΔLI=-9-18 units), CRP and haptoglobin was higher and IgM lower in the former group (p=0.03, 0.02 and 0.03 respectively). In women with DoD 1-6 years (and only in this interval) significant linear relationships were found between ALI and hemoglobin (r-0.52, p<0.01) Ritchie index, haptoglobin, CRP (r=0.41-0.46, p<0.05) and IgM (r=-0.43, p<0.05). The mean of repeated hemoglobin values correlated even more strongly with ΔLI (r=0.70, p<0.001). ΔLI was predicted quite well by an expression linear in hemoglobin, fibrinogen and IgM (R=0.84). Similar results were obtained when male patients were included. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
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Saxne, ToreLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-tsa
(author)
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Petersson, HSkåne University Hospital
(author)
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Wollheim, FrankLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-fwo
(author)
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Skåne University HospitalReumatologi och molekylär skelettbiologi
(creator_code:org_t)
Related titles
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In:Scandinavian Journal of Rheumatology13:1, s. 21-271502-7732
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