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The Effect of Botul...
The Effect of Botulinum Toxin Type A Injections on Stricture Formation, Leakage Rates, Esophageal Elongation, and Anastomotic Healing Following Primary Anastomosis in a Long- and Short-Gap Esophageal Atresia Model : A Protocol for a Randomized, Controlled, Blinded Trial in Pigs
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- Svensson, Emma (author)
- Lund University,Lunds universitet,Kirurgi och folkhälsa,Forskargrupper vid Lunds universitet,Surgery and public health,Lund University Research Groups,Skåne University Hospital
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- Zvara, Peter (author)
- University of Southern Denmark
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- Qvist, Niels (author)
- University of Southern Denmark
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- Hagander, Lars (author)
- Lund University,Lunds universitet,Kirurgi och folkhälsa,Forskargrupper vid Lunds universitet,Barnkirurgi,Surgery and public health,Lund University Research Groups,Pediatric surgery,Skåne University Hospital
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- Möller, Sören (author)
- University of Southern Denmark
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- Rasmussen, Lars (author)
- University of Southern Denmark
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- Daa Schrøder, Henrik (author)
- University of Southern Denmark
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- Kildall Hejböl, Eva (author)
- University of Southern Denmark
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- Björn, Niels (author)
- University of Southern Denmark
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- Petersen, Susanna (author)
- University of Southern Denmark
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- Cederström Larsen, Kristine (author)
- University of Southern Denmark
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- Krhut, Jan (author)
- University of Ostrava,University Hospital Ostrava
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- Muensterer, Oliver J (author)
- Ludwig-Maximilian University of Munich
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- Bremholm Ellebaek, Mark (author)
- University of Southern Denmark
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(creator_code:org_t)
- IJS Press, 2021
- 2021
- English.
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In: International Journal of Surgery Protocols. - : IJS Press. - 2468-3574. ; 25:1, s. 171-177
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
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- Background:Esophageal atresia (EA) is a congenital malformation affecting 1:3000-4500 newborns. Approximately 15% have a long-gap EA (LGEA), in which case a primary anastomosis is often impossible to achieve. To create continuity of the esophagus patients instead have to undergo lengthening procedures or organ interpositions; methods associated with high morbidity and poor functional outcomes. Esophageal injections of Botulinum Toxin Type A (BTX-A) could enable primary anastomosis and mitigate stricture formation through decreased tissue tension.Methods and Analysis:In this randomized controlled blinded animal trial, 24 pigs are divided into a long- or short-gap EA group (LGEA and SGEA, respectively) and randomized to receive BTX-A or isotonic saline injections. In the LGEA group, injections are given endoscopically in the esophageal musculature. After seven days, a 3 cm esophageal resection and primary anastomosis is performed. In the SGEA group, a 1 cm esophageal resection and primary anastomosis is performed, followed by intraoperative injections of BTX-A or isotonic saline. After 14 days, stricture formation, presence of leakage, and esophageal compliance is assessed using endoscopic and manometric techniques, and in vivo and ex vivo contrast radiography. Tissue elongation is evaluated in a stretch-tension test, and the esophagus is assessed histologically to evaluate anastomotic healing.Ethics and Dissemination:The study complies with the ARRIVE guidelines for animal studies and has been approved by the Danish Animal Experimentation Council. Results will be published in peer-reviewed journals and presented at national and international conferences.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Svensson, Emma
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Zvara, Peter
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Qvist, Niels
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Hagander, Lars
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Möller, Sören
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Rasmussen, Lars
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Daa Schrøder, He ...
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Kildall Hejböl, ...
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Björn, Niels
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Petersen, Susann ...
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Cederström Larse ...
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Krhut, Jan
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Muensterer, Oliv ...
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Bremholm Ellebae ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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Lund University