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Common variation at...
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
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Broderick, Peter (author)
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Chubb, Daniel (author)
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Johnson, David C. (author)
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Weinhold, Niels (author)
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Foersti, Asta (author)
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Lloyd, Amy (author)
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Olver, Bianca (author)
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Ma, Yussanne P. (author)
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Dobbins, Sara E. (author)
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Walker, Brian A. (author)
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Davies, Faith E. (author)
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Gregory, Walter A. (author)
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Child, J. Anthony (author)
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Ross, Fiona M. (author)
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Jackson, Graham H. (author)
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Neben, Kai (author)
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Jauch, Anna (author)
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Hoffmann, Per (author)
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Muehleisen, Thomas W. (author)
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Noethen, Markus M. (author)
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Moebus, Susanne (author)
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Tomlinson, Ian P. (author)
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Goldschmidt, Hartmut (author)
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Morgan, Gareth J. (author)
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Houlston, Richard S. (author)
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(creator_code:org_t)
- 2011-11-27
- 2012
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:1, s. 58-83
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Abstract
Subject headings
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- To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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- By the author/editor
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Broderick, Peter
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Chubb, Daniel
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Johnson, David C ...
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Weinhold, Niels
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Foersti, Asta
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Lloyd, Amy
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show more...
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Olver, Bianca
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Ma, Yussanne P.
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Dobbins, Sara E.
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Walker, Brian A.
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Davies, Faith E.
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Gregory, Walter ...
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Child, J. Anthon ...
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Ross, Fiona M.
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Jackson, Graham ...
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Neben, Kai
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Jauch, Anna
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Hoffmann, Per
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Muehleisen, Thom ...
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Noethen, Markus ...
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Moebus, Susanne
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Tomlinson, Ian P ...
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Goldschmidt, Har ...
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Hemminki, Kari
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Morgan, Gareth J ...
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Houlston, Richar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Nature Genetics
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Lund University