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Lysates of Methyloc...
Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
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- Jensen, Benjamin A H (author)
- University of Copenhagen
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- Holm, Jacob B (author)
- University of Copenhagen
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- Larsen, Ida S (author)
- University of Copenhagen
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- von Burg, Nicole (author)
- Technical University of Denmark
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- Derer, Stefanie (author)
- University Medical Center Schleswig-Holstein
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- Sonne, Si B (author)
- University of Copenhagen
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- Pærregaard, Simone I (author)
- University of Copenhagen
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- Damgaard, Mads V (author)
- University of Copenhagen
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- Indrelid, Stine A (author)
- Norwegian University of Life Sciences
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- Rivollier, Aymeric (author)
- Technical University of Denmark
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- Agrinier, Anne-Laure (author)
- Laval University
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- Sulek, Karolina (author)
- University of Copenhagen
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- Arnoldussen, Yke J (author)
- Norwegian University of Life Sciences
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- Fjære, Even (author)
- Norwegian Institute of Marine Research
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- Marette, André (author)
- Laval University
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- Angell, Inga L (author)
- Norwegian University of Life Sciences
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- Rudi, Knut (author)
- Norwegian University of Life Sciences
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- Treebak, Jonas T (author)
- University of Copenhagen
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- Madsen, Lise (author)
- University of Copenhagen
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- Åkesson, Caroline Piercey (author)
- Norwegian University of Life Sciences
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- Agace, William (author)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Technical University of Denmark
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- Sina, Christian (author)
- University Medical Center Schleswig-Holstein
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- Kleiveland, Charlotte R (author)
- Norwegian University of Life Sciences
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- Kristiansen, Karsten (author)
- University of Copenhagen
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- Lea, Tor E (author)
- Norwegian University of Life Sciences
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(creator_code:org_t)
- 2021-02-17
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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https://www.nature.c...
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Abstract
Subject headings
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- Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Animals
- Diet
- Forkhead Transcription Factors/immunology
- Homeostasis/immunology
- Interleukin-17/immunology
- Intestine, Large/immunology
- Intestine, Small/immunology
- Male
- Methylococcus capsulatus/chemistry
- Mice, Inbred C57BL
- Microbiota/immunology
- Nuclear Receptor Subfamily 1, Group F, Member 3/immunology
- Obesity/immunology
- Proteins/immunology
- T-Lymphocytes, Regulatory/immunology
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Jensen, Benjamin ...
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Holm, Jacob B
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Larsen, Ida S
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von Burg, Nicole
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Derer, Stefanie
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Sonne, Si B
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show more...
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Pærregaard, Simo ...
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Damgaard, Mads V
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Indrelid, Stine ...
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Rivollier, Aymer ...
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Agrinier, Anne-L ...
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Sulek, Karolina
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Arnoldussen, Yke ...
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Fjære, Even
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Marette, André
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Angell, Inga L
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Rudi, Knut
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Treebak, Jonas T
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Madsen, Lise
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Åkesson, Carolin ...
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Agace, William
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Sina, Christian
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Kleiveland, Char ...
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Kristiansen, Kar ...
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Lea, Tor E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University