Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

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Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

Jensen, Benjamin A H (author): University of Copenhagen

Holm, Jacob B (author): University of Copenhagen

Larsen, Ida S (author): University of Copenhagen

von Burg, Nicole (author): Technical University of Denmark

Derer, Stefanie (author): University Medical Center Schleswig-Holstein

Sonne, Si B (author): University of Copenhagen

Pærregaard, Simone I (author): University of Copenhagen

Damgaard, Mads V (author): University of Copenhagen

Indrelid, Stine A (author): Norwegian University of Life Sciences

Rivollier, Aymeric (author): Technical University of Denmark

Agrinier, Anne-Laure (author): Laval University

Sulek, Karolina (author): University of Copenhagen

Arnoldussen, Yke J (author): Norwegian University of Life Sciences

Fjære, Even (author): Norwegian Institute of Marine Research

Marette, André (author): Laval University

Angell, Inga L (author): Norwegian University of Life Sciences

Rudi, Knut (author): Norwegian University of Life Sciences

Treebak, Jonas T (author): University of Copenhagen

Madsen, Lise (author): University of Copenhagen

Åkesson, Caroline Piercey (author): Norwegian University of Life Sciences

Agace, William (author): Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Technical University of Denmark

Sina, Christian (author): University Medical Center Schleswig-Holstein

Kleiveland, Charlotte R (author): Norwegian University of Life Sciences

Kristiansen, Karsten (author): University of Copenhagen

Lea, Tor E (author): Norwegian University of Life Sciences

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2021-02-17
2021
English.
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1

Related links:: http://dx.doi.org/10... (free); show more...; https://www.nature.c...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Interactions between host and gut microbial communities are modulated by diets and play pivotal roles in immunological homeostasis and health. We show that exchanging the protein source in a high fat, high sugar, westernized diet from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath is sufficient to reverse western diet-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22 °C) and at thermoneutrality (T30 °C). Concomitant with microbiota changes, mice fed the Methylococcus-based western diet exhibit improved glucose regulation, reduced body and liver fat, and diminished hepatic immune infiltration. Intake of the Methylococcu-based diet markedly boosts Parabacteroides abundances in a manner depending on adaptive immunity, and upregulates triple positive (Foxp3+RORγt+IL-17+) regulatory T cells in the small and large intestine. Collectively, these data point to the potential for leveraging the use of McB lysates to improve immunometabolic homeostasis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

Animals
Diet
Forkhead Transcription Factors/immunology
Homeostasis/immunology
Interleukin-17/immunology
Intestine, Large/immunology
Intestine, Small/immunology
Male
Methylococcus capsulatus/chemistry
Mice, Inbred C57BL
Microbiota/immunology
Nuclear Receptor Subfamily 1, Group F, Member 3/immunology
Obesity/immunology
Proteins/immunology
T-Lymphocytes, Regulatory/immunology

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art (subject category)
ref (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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By the university: Lund University

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