Search: onr:"swepub:oai:lup.lub.lu.se:2f96c66f-a956-4042-b0ee-302435da9545" > Heart rate is assoc...
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000 | 03934naa a2200481 4500 | |
001 | oai:lup.lub.lu.se:2f96c66f-a956-4042-b0ee-302435da9545 | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/74251942 URI |
024 | 7 | a https://doi.org/10.1136/heartjnl-2014-3070432 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Holmqvist, Fredriku Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Duke University4 aut0 (Swepub:lu)kard-fho |
245 | 1 0 | a Heart rate is associated with progression of atrial fibrillation, independent of rhythm |
264 | c 2015-03-02 | |
264 | 1 | b BMJ,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Objective Atrial fibrillation (AF) often progresses from paroxysmal or persistent to more sustained forms, but the rate and predictors of AF progression in clinical practice are not well described. Methods Using the Outcomes Registry for Better Informed Treatment of AF, we analysed the incidence and predictors of progression and tested the discrimination and calibration of the HATCH (hypertension, age, TIA/stroke, chronic obstructive pulmonary disease, heart failure) and CHA(2)DS(2)VASc scores for identifying AF progression. Results Among 6235 patients with paroxysmal or persistent AF at baseline, 1479 progressed, during follow-up (median 18 (IQR 12-24) months). These patients were older and had more comorbidities than patients who did not progress (CHADS(2) 2.3 +/- 1.3 vs 2.1 +/- 1.3, p<0.0001). At baseline, patients with AF progression were more often on a rate control as opposed to a rhythm control strategy (66 vs 56%, p<0.0001) and had higher heart rate (72(64-80) vs 68 (60-76) bpm, p<0.0001). The strongest predictors of AF progression were AF on the baseline ECG (OR 2.30, 95% CI 1.95 to 2.73, p<0.0001) and increasing age (OR 1.16, 95% CI1.09 to 1.24, p<0.0001, per 10 increase), while patients with lower heart rate (OR 0.84, 95% CI 0.79 to 0.89, p<0.0001, per 10 decrease <= 80) were less likely to progress. There was no significant interaction between rhythm on baseline ECG and heart rate (p=0.71). The HATCH and CHA(2)DS(2)VASc scores had modest discriminatory power for AF progression (C-indices 0.55 (95% CI 0.53 to 0.58) and 0.55 (95% CI 0.52 to 0.57)). Conclusions Within 1.5 years, almost a quarter of the patients with paroxysmal or persistent AF progress to a more sustained form. Progression is strongly associated with heart rate, and age. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Kim, Sunghee4 aut |
700 | 1 | a Steinberg, Benjamin A.4 aut |
700 | 1 | a Reiffel, James A.4 aut |
700 | 1 | a Mahaffey, Kenneth W.4 aut |
700 | 1 | a Gersh, Bernard J.4 aut |
700 | 1 | a Fonarow, Gregg C.4 aut |
700 | 1 | a Naccarelli, Gerald V.4 aut |
700 | 1 | a Chang, Paul4 aut |
700 | 1 | a Freeman, James V.4 aut |
700 | 1 | a Kowey, Peter R.4 aut |
700 | 1 | a Thomas, Laine4 aut |
700 | 1 | a Peterson, Eric D.4 aut |
700 | 1 | a Piccini, Jonathan P.4 aut |
710 | 2 | a Kardiologib Sektion II4 org |
773 | 0 | t Heartd : BMJg 101:11, s. 894-899q 101:11<894-899x 1355-6037x 1468-201X |
856 | 4 | u https://portal.research.lu.se/files/1512035/8522622x primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1136/heartjnl-2014-307043x freey FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc4453487?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/7425194 |
856 | 4 8 | u https://doi.org/10.1136/heartjnl-2014-307043 |
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