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Staging Presymptoma...
Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association.
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- Insel, Richard A (author)
- Juvenile Diabetes Research Foundation
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- Dunne, Jessica L (author)
- Juvenile Diabetes Research Foundation
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- Atkinson, Mark A (author)
- University of Florida
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- Chiang, Jane L (author)
- American Diabetes Association
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- Dabelea, Dana (author)
- University of Colorado
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- Gottlieb, Peter A (author)
- University of Colorado
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- Greenbaum, Carla J (author)
- Benaroya Research Institute
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- Herold, Kevan C (author)
- Yale University
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- Krischer, Jeffrey P (author)
- University of South Florida
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ratner, Robert E (author)
- American Diabetes Association
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Rewers, Marian J (author)
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Schatz, Desmond A (author)
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Skyler, Jay S (author)
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Sosenko, Jay M (author)
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Ziegler, Anette-G (author)
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(creator_code:org_t)
- 2015-09-15
- 2015
- English.
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In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 38:10, s. 1964-1974
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Abstract
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- Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that progresses sequentially at variable but predictable rates through distinct identifiable stages prior to the onset of symptoms. Stage 1 is defined as the presence of β-cell autoimmunity as evidenced by the presence of two or more islet autoantibodies with normoglycemia and is presymptomatic, stage 2 as the presence of β-cell autoimmunity with dysglycemia and is presymptomatic, and stage 3 as onset of symptomatic disease. Adoption of this staging classification provides a standardized taxonomy for type 1 diabetes and will aid the development of therapies and the design of clinical trials to prevent symptomatic disease, promote precision medicine, and provide a framework for an optimized benefit/risk ratio that will impact regulatory approval, reimbursement, and adoption of interventions in the early stages of type 1 diabetes to prevent symptomatic disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Insel, Richard A
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Dunne, Jessica L
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Atkinson, Mark A
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Chiang, Jane L
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Dabelea, Dana
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Gottlieb, Peter ...
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show more...
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Greenbaum, Carla ...
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Herold, Kevan C
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Krischer, Jeffre ...
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Lernmark, Åke
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Ratner, Robert E
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Rewers, Marian J
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Schatz, Desmond ...
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Skyler, Jay S
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Sosenko, Jay M
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Ziegler, Anette- ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University