SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:3036200e-75db-418b-bade-dbfc954ba184"
 

Search: onr:"swepub:oai:lup.lub.lu.se:3036200e-75db-418b-bade-dbfc954ba184" > Measurements of med...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Clerx, Lies (author)

Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Elsevier BV,2013

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3036200e-75db-418b-bade-dbfc954ba184
  • https://lup.lub.lu.se/record/3920824URI
  • https://doi.org/10.1016/j.neurobiolaging.2013.02.002DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127001819URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI. (c) 2013 Elsevier Inc. All rights reserved.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • van Rossum, Ineke A. (author)
  • Burns, Leah (author)
  • Knol, Dirk L. (author)
  • Scheltens, Philip (author)
  • Verhey, Frans (author)
  • Aalten, Pauline (author)
  • Lapuerta, Pablo (author)
  • van de Pol, Laura (author)
  • van Schijndel, Ronald (author)
  • de Jong, Remko (author)
  • Barkhof, Frederik (author)
  • Wolz, Robin (author)
  • Rueckert, Daniel (author)
  • Bocchetta, Martina (author)
  • Tsolaki, Magdalini (author)
  • Nobili, Flavio (author)
  • Wahlund, Lars-OlafKarolinska Institutet (author)
  • Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)psyk-lmi (author)
  • Froelich, Lutz (author)
  • Hampel, Harald (author)
  • Soininen, Hilkka (author)
  • Visser, Pieter Jelle (author)
  • Karolinska InstitutetKlinisk minnesforskning (creator_code:org_t)

Related titles

  • In:Neurobiology of Aging: Elsevier BV34:8, s. 2003-20131558-14970197-4580

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view