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Harnessing androgen...
Harnessing androgen receptor pathway activation for targeted alpha particle radioimmunotherapy of breast cancer
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- Thorek, Daniel L.J. (author)
- Washington University in St. Louis
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- Ku, Anson T. (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Mitsiades, Nicholas (author)
- Baylor College of Medicine
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- Veach, Darren (author)
- Cornell University,Memorial Sloan-Kettering Cancer Center
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- Watson, Philip A. (author)
- Memorial Sloan-Kettering Cancer Center
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- Metha, Dipti (author)
- Memorial Sloan-Kettering Cancer Center
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- Strand, Sven Erik (author)
- Lund University,Lunds universitet,Forskningsgruppen för Systemisk strålterapi,Forskargrupper vid Lunds universitet,Systemic Radiation Therapy Group,Lund University Research Groups,Skåne University Hospital
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- Sharma, Sai Kiran (author)
- Memorial Sloan-Kettering Cancer Center
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- Lewis, Jason S. (author)
- Cornell University,Memorial Sloan-Kettering Cancer Center
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- Abou, Diane S. (author)
- Washington University in St. Louis
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- Lilja, Hans G. (author)
- University of Oxford,Memorial Sloan-Kettering Cancer Center
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- Larson, Steven M. (author)
- Memorial Sloan-Kettering Cancer Center
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- McDevitt, Michael R. (author)
- Cornell University,Memorial Sloan-Kettering Cancer Center
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- Ulmert, David (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, Los Angeles,Jonsson Comprehensive Cancer Center,Memorial Sloan-Kettering Cancer Center
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Washington University in St Louis Klinisk kemi, Malmö (creator_code:org_t)
- 2019
- 2019
- English 11 s.
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In: Clinical Cancer Research. - 1078-0432. ; 25:2, s. 881-891
- Related links:
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http://dx.doi.org/10...
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Abstract
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- Purpose: The impact of androgen receptor (AR) activity Results: D-Norgestrel and DHT activated the AR pathway, in breast cancer biology is unclear. We characterized and while 17b-Estradiol did not. Competitive binding for AR tested a novel therapy to an AR-governed target in breast protein showed similar affinity between DHT and D-Norges-cancer. trel, indicating direct AR–ligand interaction. In vivo production Experimental Design: We evaluated the expression of of hK2 was sufficient to achieve site-specific delivery of ther-prototypical AR gene products human kallikrein 2 (hK2) apeutic radionuclide to tumor tissue at >20-fold over back- and PSA in breast cancer models. We screened 13 well-ground muscle uptake; effecting long-term local tumor characterized breast cancer cell lines for hK2 and PSA control. production upon in vitro hormone stimulation by testoster-Conclusions: [225Ac]hu11B6 targeted radiotherapy one [dihydrotestosterone (DHT)]. AR-positive lines were was potentiated by DHT and by D-Norgestrel in murine further evaluated by exposure to estrogen (17b-Estradiol) xenograft models of breast cancer. AR activity in and the synthetic progestin D-Norgestrel. We then evaluated breast cancer correlates with kallikrein-related peptidase-2 an anti-hK2–targeted radiotherapy platform (hu11B6), and can be activated by D-Norgestrel, a common con-labeled with alpha (a)-particle emitting Actinium-225, to traceptive, and AR induction can be harnessed for hK2-specifically treat AR-expressing breast cancer xenografts targeted breast cancer a-emitter radiotherapy. under hormone stimulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Thorek, Daniel L ...
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Ku, Anson T.
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Mitsiades, Nicho ...
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Veach, Darren
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Watson, Philip A ...
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Metha, Dipti
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show more...
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Strand, Sven Eri ...
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Sharma, Sai Kira ...
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Lewis, Jason S.
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Abou, Diane S.
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Lilja, Hans G.
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Larson, Steven M ...
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McDevitt, Michae ...
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Ulmert, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
- Articles in the publication
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Clinical Cancer ...
- By the university
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Lund University