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Involvement of the serotonin system in L-dopa-induced dyskinesias
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- Carta, Manolo (author)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Carlsson, Thomas (author)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Muñoz, Ana (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
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- (creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
- In: Parkinsonism and Related Disorders. - : Elsevier BV. - 1353-8020. ; 14:Suppl 2, s. 8-154
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The ability of L-dopa to relieve the motor impairments in Parkinson's disease patients declines over time, and side-effects, such as dyskinesias, appear--limiting the use of the drug in the advanced stage of the disease. Serotonergic neurons are able to convert L-dopa to dopamine and to store this neurotransmitter in synaptic vesicles. This peculiarity might be very important in the advanced disease, when most of the dopaminergic neurons have degenerated. Indeed, an increasing body of evidence points to dopamine released as a false neurotransmitter from the serotonin terminals as the main pre-synaptic determinant of L-dopa-induced dyskinesias in animal models of Parkinson's disease. These findings make the serotonin system an intriguing target for anti-dyskinetic therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Animals
- Dopamine Agents
- Dyskinesia, Drug-Induced
- Humans
- Levodopa
- Serotonin
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Carlsson, Thomas
- Muñoz, Ana
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