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Cystatin C modulates cerebral beta-amyloidosis
- Kaeser, Stephan A. (author)
- Herzig, Martin C. (author)
- Coomaraswamy, Janaky (author)
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- Kilger, Ellen (author)
- Selenica, Maj-Linda (author)
- Winkler, David T. (author)
- Staufenbiel, Matthias (author)
- Levy, Efrat (author)
- Jucker, Mathias (author)
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- (creator_code:org_t)
- 2007-11-18
- 2007
- English.
- In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 39:12, s. 1437-1439
- Journal article (peer-reviewed)
Abstract
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- The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
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