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Meta-analysis of ge...
Meta-analysis of gene-level tests for rare variant association.
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Liu, Dajiang J (author)
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Peloso, Gina M (author)
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Zhan, Xiaowei (author)
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Holmen, Oddgeir L (author)
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Zawistowski, Matthew (author)
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Feng, Shuang (author)
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Nikpay, Majid (author)
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Auer, Paul L (author)
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Goel, Anuj (author)
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Zhang, He (author)
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Peters, Ulrike (author)
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Farrall, Martin (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Kooperberg, Charles (author)
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McPherson, Ruth (author)
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Watkins, Hugh (author)
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Willer, Cristen J (author)
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Hveem, Kristian (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Kathiresan, Sekar (author)
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Abecasis, Gonçalo R (author)
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(creator_code:org_t)
- 2013-12-15
- 2014
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:2, s. 200-200
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Abstract
Subject headings
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- The majority of reported complex disease associations for common genetic variants have been identified through meta-analysis, a powerful approach that enables the use of large sample sizes while protecting against common artifacts due to population structure and repeated small-sample analyses sharing individual-level data. As the focus of genetic association studies shifts to rare variants, genes and other functional units are becoming the focus of analysis. Here we propose and evaluate new approaches for performing meta-analysis of rare variant association tests, including burden tests, weighted burden tests, variable-threshold tests and tests that allow variants with opposite effects to be grouped together. We show that our approach retains useful features from single-variant meta-analysis approaches and demonstrate its use in a study of blood lipid levels in ∼18,500 individuals genotyped with exome arrays.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Liu, Dajiang J
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Peloso, Gina M
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Zhan, Xiaowei
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Holmen, Oddgeir ...
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Zawistowski, Mat ...
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Feng, Shuang
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show more...
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Nikpay, Majid
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Auer, Paul L
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Goel, Anuj
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Zhang, He
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Peters, Ulrike
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Farrall, Martin
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Orho-Melander, M ...
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Kooperberg, Char ...
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McPherson, Ruth
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Watkins, Hugh
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Willer, Cristen ...
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Hveem, Kristian
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Melander, Olle
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Kathiresan, Seka ...
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Abecasis, Gonçal ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University