Occurrence of gamma-trace in the calcitonin-producing C-cells of simian thyroid gland and human medullary thyroid carcinoma

• gamma-Trace, a microprotein occurring in neuroendocrine cells, was demonstrated by immunohistochemical technique to be present in the calcitonin-producing C-cells of normal simian thyroid gland and of human medullary thyroid carcinoma. A comparatively high concentration of gamma-trace was demonstrated in tissue extract of neoplastic C-cells. The immunoreactive protein found in the extract had a molecular weight and electrophoretic mobility characteristic for gamma-trace.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Adsorption

Animals

Calcitonin/metabolism

Chlorocebus aethiops

Cystatin C

Cystatins

Electrophoresis, Polyacrylamide Gel

Female

Globulins/metabolism

Growth Hormone/metabolism

Humans

Immune Sera

Immunoelectrophoresis

Immunoenzyme Techniques

Thyroid Gland/cytology

Thyroid Neoplasms/metabolism

Publication and Content Type

art (subject category)

ref (subject category)