Search: onr:"swepub:oai:lup.lub.lu.se:32b0e3df-d807-446c-81c9-d6ec30be9d36" >
Protein folding/unf...
Protein folding/unfolding in the presence of interacting macromolecular crowders
-
- Irbäck, Anders (author)
- Lund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science
-
- Mohanty, Sandipan (author)
- Jülich Research Centre
-
(creator_code:org_t)
- 2017-04-05
- 2017
- English 12 s.
-
In: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 226:4, s. 627-638
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://link.springe...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Recent years have seen an increasing number of biophysical studies of proteins being conducted in cells and concentrated protein solutions. In these experiments, compared to dilute-solution data, both stabilization and destabilization of globular proteins have been observed, which cannot be explained in terms of volume exclusion alone. For a fundamental understanding of the observed effects, there is a need for computational modeling beyond the level of hard-sphere crowders. This mini-review discusses recent efforts to simulate folding/unfolding properties of proteins in the presence of explicit macromolecular crowders. A Monte Carlo-based approach by us is described, which we recently applied to study the equilibrium folding thermodynamics of two peptides in the presence of explicit protein crowders.
Subject headings
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
To the university's database