SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:33388b1b-6894-42bf-87f1-1b93c75eaf33"
 

Search: onr:"swepub:oai:lup.lub.lu.se:33388b1b-6894-42bf-87f1-1b93c75eaf33" > Skeletal muscle fib...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004256naa a2200445 4500
001oai:lup.lub.lu.se:33388b1b-6894-42bf-87f1-1b93c75eaf33
003SwePub
008231018s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/33388b1b-6894-42bf-87f1-1b93c75eaf332 URI
0247 a https://doi.org/10.3389/fpubh.2023.11223932 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Christensen, Dirk L.u University of Copenhagen4 aut
2451 0a Skeletal muscle fibre type and enzymatic activity in adult offspring following placental and peripheral malaria exposure in foetal life
264 1c 2023
520 a Background: Maternal malaria may restrict foetal growth. Impaired utero-placental blood flow due to malaria infection may cause hypoxia-induced altered skeletal muscle fibre type distribution in the offspring, which may contribute to insulin resistance and impaired glucose metabolism. This study assessed muscle fibre distribution 20 years after placental and/or peripheral in-utero malaria exposure compared to no exposure, i.e., PPM+, PM+, and M-, respectively. Methods: We traced 101 men and women offspring of mothers who participated in a malaria chemosuppression study in Muheza, Tanzania. Of 76 eligible participants, 50 individuals (29 men and 21 women) had skeletal muscle biopsy taken from m. vastus lateralis in the right leg. As previously reported, fasting and 30 min post-oral glucose challenge plasma glucose values were higher, and insulin secretion disposition index was lower, in the PPM+ group. Aerobic capacity (fitness) was estimated by an indirect VO2max test on a stationary bicycle. Muscle fibre sub-type (myosin heavy chain, MHC) distribution was analysed, as were muscle enzyme activities (citrate synthase (CS), 3-hydroxyacyl-CoA dehydrogenase, myophosphorylase, phosphofructokinase, lactate dehydrogenase, and creatine kinase activities. Between-group analyses were adjusted for MHC-I %. Results: No differences in aerobic capacity were found between groups. Despite subtle elevations of plasma glucose levels in the PPM+ group, there was no difference in MHC sub-types or muscle enzymatic activities between the malaria-exposed and non-exposed groups. Conclusion: The current study did not show differences in MHC towards glycolytic sub-types or enzymatic activity across the sub-groups. The results support the notion of the mild elevations of plasma glucose levels in people exposed to placental malaria in pregnancy being due to compromised pancreatic insulin secretion rather than insulin resistance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653 a glucose metabolism
653 a hypoxia
653 a malaria exposure
653 a myosin heavy chain
653 a skeletal muscle enzymes
7001 a Mutabingwa, Theonest K.u Hubert Kairuki Memorial University4 aut
7001 a Bygbjerg, Ib C.u University of Copenhagen4 aut
7001 a Vaag, Allan A.u Lund University,Lunds universitet,Translationell diabetesforskning,Forskargrupper vid Lunds universitet,Translational Diabetes Research,Lund University Research Groups,Steno Diabetes Center Copenhagen4 aut0 (Swepub:lu)med-ava
7001 a Grunnet, Louise G.u University of Copenhagen,Steno Diabetes Center Copenhagen4 aut
7001 a Lajeunesse-Trempe, Fannyu Laval University4 aut
7001 a Nielsen, Jannieu University of Copenhagen4 aut
7001 a Schmiegelow, Christentzeu University of Copenhagen4 aut
7001 a Ramaiya, Kaushik L.u Shree Hindu Mandal Hospital4 aut
7001 a Myburgh, Kathryn H.u Stellenbosch University4 aut
7102 a University of Copenhagenb Hubert Kairuki Memorial University4 org
7730 t Frontiers in Public Healthg 11q 11x 2296-2565
8564 u http://dx.doi.org/10.3389/fpubh.2023.1122393x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/33388b1b-6894-42bf-87f1-1b93c75eaf33
8564 8u https://doi.org/10.3389/fpubh.2023.1122393

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view