Search: onr:"swepub:oai:lup.lub.lu.se:3361d6e4-9612-45bc-8604-c96f5e2feb42" >
Early Brain Volume ...
Early Brain Volume Changes After Stroke : Subgroup Analysis From the AXIS-2 Trial
-
- Bu, Ning (author)
- The Florey Institute of Neuroscience and Mental Health,Second Affiliated Hospital of Xi'an Jiaotong University
-
- Churilov, Leonid (author)
- University of Melbourne
-
- Khlif, Mohamed Salah (author)
- The Florey Institute of Neuroscience and Mental Health
-
show more...
-
- Lemmens, Robin (author)
- University Hospitals Leuven,Flanders Interuniversity Institute for Biotechnology
-
- Wouters, Anke (author)
- University Hospitals Leuven,Flanders Interuniversity Institute for Biotechnology
-
- Fiebach, Jochen B. (author)
- Charité - University Medicine Berlin
-
- Chamorro, Angel (author)
- University of Barcelona
-
- Ringelstein, E. Bernd (author)
- University of Münster
-
- Norrving, Bo (author)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research
-
- Laage, Rico (author)
- Guided Development GmbH
-
- Grond, Martin (author)
- Philipp University of Marburg
-
- Wilms, Guido (author)
- University Hospitals Leuven
-
- Brodtmann, Amy (author)
- The Florey Institute of Neuroscience and Mental Health
-
- Thijs, Vincent (author)
- The Florey Institute of Neuroscience and Mental Health
-
show less...
-
(creator_code:org_t)
- 2022-01-28
- 2022
- English.
-
In: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 12
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://www.frontier...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Background and Purpose: The evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month after stroke was assessed using unified segmentation in SPM12. We hypothesized that age, ischemic brain lesion size, and white matter (WM) changes were associated with larger brain volume change. Enlarged perivascular spaces (EPVSs) and white matter hyperintensities (WMHs) were rated visually and the presence of lacunes was assessed. Results: We enrolled 173 patients with a mean age of 67 ± 11 years, 44% were women. There was a median 6 ml decrease in volume (25th percentile −1 ml to 75th percentile 21 ml) over time, equivalent to a median 0.5% (interquartile range [IQR], −0.07%−1.4%), decrease in brain volume. Age was associated with larger brain volume loss (per 10 years of age, 5 ml 95% CI 2–8 ml). Baseline diffusion weighted imaging (DWI) lesion volume was not associated with greater volume loss per 10 ml of lesion volume, change by 0 ml (95% CI −0.1 to 0.1 ml). Increasing Fazekas scores of deep WMH were associated with greater tissue loss (5 ml, 95% CI 1–10 ml). Conclusions: Total brain volume changes in a heterogenous fashion after stroke. Volume loss occurs over 1 month after stroke and is associated with age and deep WM disease. We did not find evidence that more severe strokes lead to increased early tissue loss.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- atrophy
- brain volume changes
- clinical trial
- edema
- hemorrhagic transformation
- ischemic stroke
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bu, Ning
-
Churilov, Leonid
-
Khlif, Mohamed S ...
-
Lemmens, Robin
-
Wouters, Anke
-
Fiebach, Jochen ...
-
show more...
-
Chamorro, Angel
-
Ringelstein, E. ...
-
Norrving, Bo
-
Laage, Rico
-
Grond, Martin
-
Wilms, Guido
-
Brodtmann, Amy
-
Thijs, Vincent
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Frontiers in Neu ...
- By the university
-
Lund University