Search: onr:"swepub:oai:lup.lub.lu.se:3361d6e4-9612-45bc-8604-c96f5e2feb42" >
Early Brain Volume ...
-
Bu, NingThe Florey Institute of Neuroscience and Mental Health,Second Affiliated Hospital of Xi'an Jiaotong University
(author)
Early Brain Volume Changes After Stroke : Subgroup Analysis From the AXIS-2 Trial
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2022-01-28
-
Frontiers Media SA,2022
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:3361d6e4-9612-45bc-8604-c96f5e2feb42
-
https://lup.lub.lu.se/record/3361d6e4-9612-45bc-8604-c96f5e2feb42URI
-
https://doi.org/10.3389/fneur.2021.747343DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background and Purpose: The evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month after stroke was assessed using unified segmentation in SPM12. We hypothesized that age, ischemic brain lesion size, and white matter (WM) changes were associated with larger brain volume change. Enlarged perivascular spaces (EPVSs) and white matter hyperintensities (WMHs) were rated visually and the presence of lacunes was assessed. Results: We enrolled 173 patients with a mean age of 67 ± 11 years, 44% were women. There was a median 6 ml decrease in volume (25th percentile −1 ml to 75th percentile 21 ml) over time, equivalent to a median 0.5% (interquartile range [IQR], −0.07%−1.4%), decrease in brain volume. Age was associated with larger brain volume loss (per 10 years of age, 5 ml 95% CI 2–8 ml). Baseline diffusion weighted imaging (DWI) lesion volume was not associated with greater volume loss per 10 ml of lesion volume, change by 0 ml (95% CI −0.1 to 0.1 ml). Increasing Fazekas scores of deep WMH were associated with greater tissue loss (5 ml, 95% CI 1–10 ml). Conclusions: Total brain volume changes in a heterogenous fashion after stroke. Volume loss occurs over 1 month after stroke and is associated with age and deep WM disease. We did not find evidence that more severe strokes lead to increased early tissue loss.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Churilov, LeonidUniversity of Melbourne
(author)
-
Khlif, Mohamed SalahThe Florey Institute of Neuroscience and Mental Health
(author)
-
Lemmens, RobinUniversity Hospitals Leuven,Flanders Interuniversity Institute for Biotechnology
(author)
-
Wouters, AnkeUniversity Hospitals Leuven,Flanders Interuniversity Institute for Biotechnology
(author)
-
Fiebach, Jochen B.Charité - University Medicine Berlin
(author)
-
Chamorro, AngelUniversity of Barcelona
(author)
-
Ringelstein, E. BerndUniversity of Münster
(author)
-
Norrving, BoLund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research(Swepub:lu)neur-bno
(author)
-
Laage, RicoGuided Development GmbH
(author)
-
Grond, MartinPhilipp University of Marburg
(author)
-
Wilms, GuidoUniversity Hospitals Leuven
(author)
-
Brodtmann, AmyThe Florey Institute of Neuroscience and Mental Health
(author)
-
Thijs, VincentThe Florey Institute of Neuroscience and Mental Health
(author)
-
The Florey Institute of Neuroscience and Mental HealthSecond Affiliated Hospital of Xi'an Jiaotong University
(creator_code:org_t)
Related titles
-
In:Frontiers in Neurology: Frontiers Media SA121664-2295
Internet link
Find in a library
To the university's database
- By the author/editor
-
Bu, Ning
-
Churilov, Leonid
-
Khlif, Mohamed S ...
-
Lemmens, Robin
-
Wouters, Anke
-
Fiebach, Jochen ...
-
show more...
-
Chamorro, Angel
-
Ringelstein, E. ...
-
Norrving, Bo
-
Laage, Rico
-
Grond, Martin
-
Wilms, Guido
-
Brodtmann, Amy
-
Thijs, Vincent
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Frontiers in Neu ...
- By the university
-
Lund University