SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:3361d6e4-9612-45bc-8604-c96f5e2feb42"
 

Search: onr:"swepub:oai:lup.lub.lu.se:3361d6e4-9612-45bc-8604-c96f5e2feb42" > Early Brain Volume ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Bu, NingThe Florey Institute of Neuroscience and Mental Health,Second Affiliated Hospital of Xi'an Jiaotong University (author)

Early Brain Volume Changes After Stroke : Subgroup Analysis From the AXIS-2 Trial

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-28
  • Frontiers Media SA,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3361d6e4-9612-45bc-8604-c96f5e2feb42
  • https://lup.lub.lu.se/record/3361d6e4-9612-45bc-8604-c96f5e2feb42URI
  • https://doi.org/10.3389/fneur.2021.747343DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background and Purpose: The evolution of total brain volume early after stroke is not well understood. We investigated the associations between age and imaging features and brain volume change in the first month after stroke. Methods: We retrospectively studied patients with acute ischemic stroke enrolled in the AXIS-2 trial. Total brain volume change from hyperacute MRI data to the first month after stroke was assessed using unified segmentation in SPM12. We hypothesized that age, ischemic brain lesion size, and white matter (WM) changes were associated with larger brain volume change. Enlarged perivascular spaces (EPVSs) and white matter hyperintensities (WMHs) were rated visually and the presence of lacunes was assessed. Results: We enrolled 173 patients with a mean age of 67 ± 11 years, 44% were women. There was a median 6 ml decrease in volume (25th percentile −1 ml to 75th percentile 21 ml) over time, equivalent to a median 0.5% (interquartile range [IQR], −0.07%−1.4%), decrease in brain volume. Age was associated with larger brain volume loss (per 10 years of age, 5 ml 95% CI 2–8 ml). Baseline diffusion weighted imaging (DWI) lesion volume was not associated with greater volume loss per 10 ml of lesion volume, change by 0 ml (95% CI −0.1 to 0.1 ml). Increasing Fazekas scores of deep WMH were associated with greater tissue loss (5 ml, 95% CI 1–10 ml). Conclusions: Total brain volume changes in a heterogenous fashion after stroke. Volume loss occurs over 1 month after stroke and is associated with age and deep WM disease. We did not find evidence that more severe strokes lead to increased early tissue loss.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Churilov, LeonidUniversity of Melbourne (author)
  • Khlif, Mohamed SalahThe Florey Institute of Neuroscience and Mental Health (author)
  • Lemmens, RobinUniversity Hospitals Leuven,Flanders Interuniversity Institute for Biotechnology (author)
  • Wouters, AnkeUniversity Hospitals Leuven,Flanders Interuniversity Institute for Biotechnology (author)
  • Fiebach, Jochen B.Charité - University Medicine Berlin (author)
  • Chamorro, AngelUniversity of Barcelona (author)
  • Ringelstein, E. BerndUniversity of Münster (author)
  • Norrving, BoLund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research(Swepub:lu)neur-bno (author)
  • Laage, RicoGuided Development GmbH (author)
  • Grond, MartinPhilipp University of Marburg (author)
  • Wilms, GuidoUniversity Hospitals Leuven (author)
  • Brodtmann, AmyThe Florey Institute of Neuroscience and Mental Health (author)
  • Thijs, VincentThe Florey Institute of Neuroscience and Mental Health (author)
  • The Florey Institute of Neuroscience and Mental HealthSecond Affiliated Hospital of Xi'an Jiaotong University (creator_code:org_t)

Related titles

  • In:Frontiers in Neurology: Frontiers Media SA121664-2295

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view