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Prospective virome ...
Prospective virome analyses in young children at increased genetic risk for type 1 diabetes
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- Vehik, Kendra (author)
- University of South Florida
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- Lynch, Kristian F (author)
- University of South Florida
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- Wong, Matthew C (author)
- Baylor College of Medicine
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Tian, Xiangjun (author)
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Ross, Matthew C (author)
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- Gibbs, Richard A (author)
- Baylor College of Medicine
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Ajami, Nadim J (author)
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Petrosino, Joseph F (author)
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- Rewers, Marian (author)
- University of Colorado-Denver
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- Toppari, Jorma (author)
- University of Turku
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- Ziegler, Anette G (author)
- Helmholtz Zentrum München
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- She, Jin-Xiong (author)
- Medical College of Georgia
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- Lernmark, Ake (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Hagopian, William A (author)
- Pacific Northwest Research Institute
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- Schatz, Desmond A (author)
- University of Florida
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- Krischer, Jeffrey P (author)
- University of South Florida
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- Hyöty, Heikki (author)
- Pirkanmaa Hospital District
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- Lloyd, Richard E (author)
- Baylor College of Medicine
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(creator_code:org_t)
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- 2019-12-02
- 2019
- English 8 s.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 25:12, s. 1865-1872
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Abstract
Subject headings
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- Viruses are implicated in autoimmune destruction of pancreatic islet β cells, which results in insulin deficiency and type 1 diabetes (T1D)1-4. Certain enteroviruses can infect β cells in vitro5, have been detected in the pancreatic islets of patients with T1D6 and have shown an association with T1D in meta-analyses4. However, establishing consistency in findings across studies has proven difficult. Obstacles to convincingly linking RNA viruses to islet autoimmunity may be attributed to rapid viral mutation rates, the cyclical periodicity of viruses7 and the selection of variants with altered pathogenicity and ability to spread in populations. β cells strongly express cell-surface coxsackie and adenovirus receptor (CXADR) genes, which can facilitate enterovirus infection8. Studies of human pancreata and cultured islets have shown significant variation in enteroviral virulence to β cells between serotypes and within the same serotype9,10. In this large-scale study of known eukaryotic DNA and RNA viruses in stools from children, we evaluated fecally shed viruses in relation to islet autoimmunity and T1D. This study showed that prolonged enterovirus B rather than independent, short-duration enterovirus B infections may be involved in the development of islet autoimmunity, but not T1D, in some young children. Furthermore, we found that fewer early-life human mastadenovirus C infections, as well as CXADR rs6517774, independently correlated with islet autoimmunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- By the author/editor
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Vehik, Kendra
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Lynch, Kristian ...
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Wong, Matthew C
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Tian, Xiangjun
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Ross, Matthew C
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Gibbs, Richard A
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show more...
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Ajami, Nadim J
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Petrosino, Josep ...
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Rewers, Marian
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Toppari, Jorma
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Ziegler, Anette ...
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She, Jin-Xiong
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Lernmark, Ake
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Akolkar, Beena
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Hagopian, Willia ...
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Schatz, Desmond ...
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Krischer, Jeffre ...
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Hyöty, Heikki
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Lloyd, Richard E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Medicine
- By the university
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Lund University