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Combinations of cer...
Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect
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- Arena, Mattia Pia (author)
- University of Foggia
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- Russo, Pasquale (author)
- Promis Biotech srl
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- Capozzi, Vittorio (author)
- University of Foggia
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- Rascón, Ana (author)
- Lund University,Lunds universitet,Centrum för preventiv livsmedelsforskning,Universitetets särskilda verksamheter,Food for Health Science Centre,University Specialised Centres,Aventure AB
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- Felis, Giovanna E. (author)
- University of Verona
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- Spano, Giuseppe (author)
- University of Foggia
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- Fiocco, Daniela (author)
- University of Foggia
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English 12 s.
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In: Journal of Functional Foods. - : Elsevier BV. - 1756-4646. ; 23, s. 12-23
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.
Subject headings
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Beta Glucan (PubChem CID: 9202437)
- Immune system
- Prebiotics
- Probiotics
- Relative gene expression
- Synbiotics
- β-glucan
Publication and Content Type
- art (subject category)
- ref (subject category)
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