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Apelin promotes blo...
Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
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- Berta, Judit (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Török, Szilvia (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Tárnoki-Zách, Júlia (author)
- Eötvös Loránd University
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- Drozdovszky, Orsolya (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Tóvári, József (author)
- National Institute of Oncology, Budapest
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- Paku, Sándor (author)
- Semmelweis University
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- Kovács, Ildikó (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Czirók, András (author)
- University of Kansas,University of Kansas Cancer Center,Eötvös Loránd University
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- Masri, Bernard (author)
- Institut Cochin
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- Megyesfalvi, Zsolt (author)
- Medical University of Vienna,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Oskolás, Henriett (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Malm, Johan (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Ingvar, Christian (author)
- Skåne University Hospital
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- Markó-Varga, György (author)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups
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- Döme, Balázs (author)
- Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna,National Institute of Oncology, Budapest
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- László, Viktória (author)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna
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(creator_code:org_t)
- 2021-03-11
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
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Abstract
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- Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin signaling in the malignant behavior of cutaneous melanoma. Murine B16 and human A375 melanoma cell lines were stably transfected with apelin encoding or control vectors. Apelin overexpression significantly increased melanoma cell migration and invasion in vitro, but it had no impact on its proliferation. In our in vivo experiments, apelin significantly increased the number and size of lung metastases of murine melanoma cells. Melanoma cell proliferation rates and lymph and blood microvessel densities were significantly higher in the apelin-overexpressing pulmonary metastases. APJ inhibition by the competitive APJ antagonist MM54 significantly attenuated the in vivo pro-tumorigenic effects of apelin. Additionally, we detected significantly elevated circulating apelin and VEGF levels in patients with melanoma compared to healthy controls. Our results show that apelin promotes blood and lymphatic vascularization and the growth of pulmonary metastases of skin melanoma. Further studies are warranted to validate apelin signaling as a new potential therapeutic target in this malignancy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Berta, Judit
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Török, Szilvia
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Tárnoki-Zách, Jú ...
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Drozdovszky, Ors ...
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Tóvári, József
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Paku, Sándor
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Kovács, Ildikó
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Czirók, András
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Masri, Bernard
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Megyesfalvi, Zso ...
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Oskolás, Henriet ...
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Malm, Johan
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Ingvar, Christia ...
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Markó-Varga, Gyö ...
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Döme, Balázs
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László, Viktória
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Scientific Repor ...
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Lund University