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  • Berta, JuditNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (author)

Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-03-11
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:34670b99-ee51-47ad-90a5-44d3c335542f
  • https://lup.lub.lu.se/record/34670b99-ee51-47ad-90a5-44d3c335542fURI
  • https://doi.org/10.1038/s41598-021-85162-0DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin signaling in the malignant behavior of cutaneous melanoma. Murine B16 and human A375 melanoma cell lines were stably transfected with apelin encoding or control vectors. Apelin overexpression significantly increased melanoma cell migration and invasion in vitro, but it had no impact on its proliferation. In our in vivo experiments, apelin significantly increased the number and size of lung metastases of murine melanoma cells. Melanoma cell proliferation rates and lymph and blood microvessel densities were significantly higher in the apelin-overexpressing pulmonary metastases. APJ inhibition by the competitive APJ antagonist MM54 significantly attenuated the in vivo pro-tumorigenic effects of apelin. Additionally, we detected significantly elevated circulating apelin and VEGF levels in patients with melanoma compared to healthy controls. Our results show that apelin promotes blood and lymphatic vascularization and the growth of pulmonary metastases of skin melanoma. Further studies are warranted to validate apelin signaling as a new potential therapeutic target in this malignancy.

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  • Török, SzilviaNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (author)
  • Tárnoki-Zách, JúliaEötvös Loránd University (author)
  • Drozdovszky, OrsolyaNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (author)
  • Tóvári, JózsefNational Institute of Oncology, Budapest (author)
  • Paku, SándorSemmelweis University (author)
  • Kovács, IldikóNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (author)
  • Czirók, AndrásEötvös Loránd University,University of Kansas Cancer Center,University of Kansas (author)
  • Masri, BernardInstitut Cochin (author)
  • Megyesfalvi, ZsoltNational Institute of Oncology, Budapest,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna (author)
  • Oskolás, HenriettLund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-hk- (author)
  • Malm, JohanLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-jma (author)
  • Ingvar, ChristianSkåne University Hospital(Swepub:lu)kir-cin (author)
  • Markó-Varga, GyörgyLund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups(Swepub:lu)akem-gmv (author)
  • Döme, BalázsNational Institute of Oncology, Budapest,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna(Swepub:lu)ba1464do (author)
  • László, ViktóriaNational Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna (author)
  • National Korányi Institute for Tuberculosis and Pulmonology, HungaryEötvös Loránd University (creator_code:org_t)

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  • In:Scientific Reports: Springer Science and Business Media LLC11:12045-2322

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