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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04819naa a2200517 4500 | |
| 001 | oai:lup.lub.lu.se:34bdd91f-6131-46be-936d-3e8cbd2e5b26 | |
| 003 | SwePub | |
| 008 | 161117s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/34bdd91f-6131-46be-936d-3e8cbd2e5b262 URI |
| 024 | 7 | a https://doi.org/10.1007/s00125-016-4095-02 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Heni, Martinu University of Tübingen,German Center for Diabetes Research4 aut |
| 245 | 1 0 | a Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity |
| 264 | c 2016-09-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 300 | a 10 s. | |
| 520 | a Aims/hypothesis: Variations in FTO are the strongest common genetic determinants of adiposity, and may partly act by influencing dopaminergic signalling in the brain leading to altered reward processing that promotes increased food intake. Therefore, we investigated the impact of such an interaction on body composition, and peripheral and brain insulin sensitivity. Methods: Participants from the Tübingen Family study (n = 2245) and the Malmö Diet and Cancer study (n = 2921) were genotyped for FTO SNP rs8050136 and ANKK1 SNP rs1800497. Insulin sensitivity in the caudate nucleus, an important reward area in the brain, was assessed by fMRI in 45 participants combined with intranasal insulin administration. Results: We found evidence of an interaction between variations in FTO and an ANKK1 polymorphism that associates with dopamine (D2) receptor density. In cases of reduced D2 receptor availability, as indicated by the ANKK1 polymorphism, FTO variation was associated with increased body fat and waist circumference and reduced peripheral insulin sensitivity. Similarly, altered central insulin sensitivity was observed in the caudate nucleus in individuals with the FTO obesity-risk allele and diminished D2 receptors. Conclusions/interpretation: The effects of variations in FTO are dependent on dopamine D2 receptor density (determined by the ANKK1 polymorphism). Carriers of both risk alleles might, therefore, be at increased risk of obesity and diabetes. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a ANKK1 | |
| 653 | a Body fat | |
| 653 | a Dopamine | |
| 653 | a FTO | |
| 653 | a Insulin sensitivity | |
| 653 | a TaqIA | |
| 700 | 1 | a Kullmann, Stephanieu University of Tübingen,German Center for Diabetes Research4 aut |
| 700 | 1 | a Ahlqvist, Emmau Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Translationell muskelforskning,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Translational Muscle Research4 aut0 (Swepub:lu)infl-eah |
| 700 | 1 | a Wagner, Robertu German Center for Diabetes Research,University of Tübingen4 aut |
| 700 | 1 | a Machicao, Faustou German Center for Diabetes Research,University of Tübingen4 aut |
| 700 | 1 | a Staiger, Haraldu University of Tübingen,German Center for Diabetes Research4 aut |
| 700 | 1 | a Häring, Hans Ulrichu German Center for Diabetes Research,University of Tübingen4 aut |
| 700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Translationell muskelforskning,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Translational Muscle Research4 aut0 (Swepub:lu)endo-pal |
| 700 | 1 | a Groop, Leif C.u Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Translationell muskelforskning,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Translational Muscle Research,University of Helsinki4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Small, Dana M.u Yale University,John B Pierce Laboratory4 aut |
| 700 | 1 | a Fritsche, Andreasu University of Tübingen,German Center for Diabetes Research4 aut |
| 700 | 1 | a Preissl, Hubertu Helmholtz Zentrum München4 aut |
| 710 | 2 | a University of Tübingenb German Center for Diabetes Research4 org |
| 773 | 0 | t Diabetologiad : Springer Science and Business Media LLCg 59:12, s. 2622-2631q 59:12<2622-2631x 0012-186Xx 1432-0428 |
| 856 | 4 | u http://dx.doi.org/10.1007/s00125-016-4095-0y FULLTEXT |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00125-016-4095-0.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/34bdd91f-6131-46be-936d-3e8cbd2e5b26 |
| 856 | 4 8 | u https://doi.org/10.1007/s00125-016-4095-0 |
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