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Association study i...
Association study identifying polymorphisms in CD47 and other extracellular matrix pathway genes as putative prognostic markers for colorectal cancer
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Lascorz, Jess (author)
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Bevier, Melanie (author)
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v. Schoenfels, Witigo (author)
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Kalthoff, Holger (author)
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Aselmann, Heiko (author)
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Beckmann, Jan (author)
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Egberts, Jan (author)
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Buch, Stephan (author)
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Becker, Thomas (author)
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Schreiber, Stefan (author)
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Hampe, Jochen (author)
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Schafmayer, Clemens (author)
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- 2012-07-28
- 2013
- English.
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In: International Journal of Colorectal Disease. - : Springer Science and Business Media LLC. - 1432-1262 .- 0179-1958. ; 28:2, s. 173-181
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis. Putative regulatory single nucleotide polymorphisms (SNPs) in genes from the ECM pathway were genotyped in 613 CRC patients from Northern Germany (PopGen cohort) and tested for association with disease progression and survival. The eSNP (SNP associated with expression) rs12695175 in CD47 associated with CRC specific survival (HR = 2.18, 95 % CI 1.10-4.33, CC versus AA) and with overall survival (HR = 1.99, 95 % CI 1.04-3.81, CC versus AA). This association remained significant after adjustment for age at diagnosis, tumour stage (T) and lymph node status (N). Three polymorphisms in CD47 were associated with distant metastasis in a dominant model: rs9879947 and rs3206652 in the 3'-UTR (OR = 1.64, 95 % CI 1.01-2.64 and OR = 1.88, 95 % CI 1.27-2.80, respectively) and the eSNP rs3804639 (OR = 1.73, 95 % CI 1.17-2.57). The novel associations of eSNPs in CD47 with worse survival and distant metastasis should be confirmed by additional studies, since increased expression of this gene has recently been shown to be an indicator of poor prognosis in cancer patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- CD47
- Colorectal cancer
- Extracellular matrix
- Prognosis
- Survival
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Lascorz, Jess
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Bevier, Melanie
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v. Schoenfels, W ...
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Kalthoff, Holger
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Aselmann, Heiko
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Beckmann, Jan
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show more...
-
Egberts, Jan
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Buch, Stephan
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Becker, Thomas
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Schreiber, Stefa ...
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Hampe, Jochen
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Hemminki, Kari
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Schafmayer, Clem ...
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Försti, Asta
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show less...
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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Lund University