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Inverse association...
Inverse association of intellectual function with very low blood lead but not with manganese exposure in Italian adolescents
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Lucchini, Roberto G. (author)
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Zoni, Silvia (author)
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Guazzetti, Stefano (author)
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Bontempi, Elza (author)
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Micheletti, Serena (author)
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- Broberg Palmgren, Karin (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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Parrinello, Giovanni (author)
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Smith, Donald R. (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Environmental Research. - : Elsevier BV. - 1096-0953 .- 0013-9351. ; 118, s. 65-71
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Abstract
Subject headings
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- Background: Pediatric lead (Pb) exposure impacts cognitive function and behavior and co-exposure to manganese (Mn) may enhance neurotoxicity. Objectives: To assess cognitive and behavioral function in adolescents with environmental exposure to Pb and Mn. Methods: In this cross sectional study, cognitive function and behavior were examined in healthy adolescents with environmental exposure to metals. The Wechsler Intelligence Scale for Children (WISC) and the Conners-Wells' Adolescent Self-Report Scale Long Form (CASS:L) were used to assess cognitive and behavioral function, respectively. ALAD polymorphisms rs1800435 and rs1139488 were measured as potential modifiers. Results: We examined 299 adolescents (49.2% females) aged 11-14 years. Blood lead (BPb) averaged 1.71 mu g/dL (median 1.5, range 0.44-10.2), mean Blood Manganese (BMn) was 11.1 mu g/dL (median 10.9, range 4.00-24.1). Average total IQ was 106.3 (verbal IQ= 102, performance IQ= 109.3). According to a multiple regression model considering the effect of other covariates, a reduction of about 2.4 IQ points resulted from a two-fold increase of BPb. The Benchmark Level of BPb associated with a loss of 1 IQ-point (BML01) was 0.19 mu g/dL, with a lower 95% confidence limit (BMLL01) of 0.11 mu g/dL. A very weak correlation resulted between BPb and the ADHD-like behavior (Kendall's tau rank correlation=0.074, p=0.07). No influence of ALAD genotype was observed on any outcome. Manganese was not associated with cognitive and behavioral outcomes, nor was there any interaction with lead. Conclusions: These findings demonstrate that very low level of lead exposure has a significant negative impact on cognitive function in adolescent children. Being an essential micro-nutrient, manganese may not cause cognitive effects at these low exposure levels. (c) 2012 Elsevier Inc. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Cognitive functions
- Lead
- Manganese
- Children
Publication and Content Type
- art (subject category)
- ref (subject category)
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